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Role of affinity in plasma cell development in the germinal center light zone.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2024 Jan 01; Vol. 221 (1). Date of Electronic Publication: 2023 Nov 08. - Publication Year :
- 2024
-
Abstract
- Protective immune responses to many pathogens depend on the development of high-affinity antibody-producing plasma cells (PC) in germinal centers (GCs). Transgenic models suggest that there is a stringent affinity-based barrier to PC development. Whether a similar high-affinity barrier regulates PC development under physiologic circumstances and the nature of the PC fate decision has not been defined precisely. Here, we use a fate-mapping approach to examine the relationship between GC B cells selected to undergo additional rounds of affinity maturation, GC pre-PC, and PC. The data show that initial PC selection overlaps with GC B cell selection, but that the PC compartment accumulates a less diverse and higher affinity collection of antibodies over time. Thus, whereas the GC continues to diversify over time, affinity-based pre-PC selection sieves the GC to enable the accumulation of a more restricted group of high-affinity antibody-secreting PC.<br /> (© 2023 ElTanbouly et al.)
- Subjects :
- B-Lymphocytes
Antibodies
Antibody-Producing Cells
Plasma Cells
Germinal Center
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 221
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 37938344
- Full Text :
- https://doi.org/10.1084/jem.20231838