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3-acetylpyridine induced behavioral dysfunction and neuronal loss in the striatum and hippocampus of adult male rats.
- Source :
-
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft [Ann Anat] 2024 Feb; Vol. 252, pp. 152185. Date of Electronic Publication: 2023 Nov 08. - Publication Year :
- 2024
-
Abstract
- 3-acetylpyridine (3-AP) is a neurotoxin that is known to mainly affect the inferior olivary nucleus (ION) in the brain stem. Although several studies have explored the effect of this neurotoxin, still further investigation is required to understand the impact of this toxin on different parts of the brain. In this research, two groups of rats were studied, the 3-AP-treated and the control groups. Behavioral, stereological, and immunohistochemical analyses were performed. The locomotor activity of the 3-AP-treated rats decreased whereas their anxiety levels were higher than in normal controls. Also, memory performance was impaired in animals in the 3-AP group. Microscopic observations showed a decline in the numerical density of neurons in the hippocampus and striatum along with gliosis. Although this toxin is used to affect the ION, it exerts a neurotoxic effect on different brain regions.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier GmbH. All rights reserved.)
- Subjects :
- Rats
Male
Animals
Hippocampus
Pyridines toxicity
Neurotoxins toxicity
Brain
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0402
- Volume :
- 252
- Database :
- MEDLINE
- Journal :
- Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
- Publication Type :
- Academic Journal
- Accession number :
- 37944830
- Full Text :
- https://doi.org/10.1016/j.aanat.2023.152185