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Roles of biochemistry data, lifestyle, and inflammation in identifying abnormal renal function in old Chinese.

Authors :
Chen CH
Wang CK
Wang CY
Chang CF
Chu TW
Source :
World journal of clinical cases [World J Clin Cases] 2023 Oct 16; Vol. 11 (29), pp. 7004-7016.
Publication Year :
2023

Abstract

Background: The incidence of chronic kidney disease (CKD) has dramatically increased in recent years, with significant impacts on patient mortality rates. Previous studies have identified multiple risk factors for CKD, but they mostly relied on the use of traditional statistical methods such as logistic regression and only focused on a few risk factors.<br />Aim: To determine factors that can be used to identify subjects with a low estimated glomerular filtration rate (L-eGFR < 60 mL/min per 1.73 m <superscript>2</superscript> ) in a cohort of 1236 Chinese people aged over 65.<br />Methods: Twenty risk factors were divided into three models. Model 1 consisted of demographic and biochemistry data. Model 2 added lifestyle data to Model 1, and Model 3 added inflammatory markers to Model 2. Five machine learning methods were used: Multivariate adaptive regression splines, eXtreme Gradient Boosting, stochastic gradient boosting, Light Gradient Boosting Machine, and Categorical Features + Gradient Boosting. Evaluation criteria included accuracy, sensitivity, specificity, area under the receiver operating characteristic curve (AUC), F-1 score, and balanced accuracy.<br />Results: A trend of increasing AUC of each was observed from Model 1 to Model 3 and reached statistical significance. Model 3 selected uric acid as the most important risk factor, followed by age, hemoglobin (Hb), body mass index (BMI), sport hours, and systolic blood pressure (SBP).<br />Conclusion: Among all the risk factors including demographic, biochemistry, and lifestyle risk factors, along with inflammation markers, UA is the most important risk factor to identify L-eGFR, followed by age, Hb, BMI, sport hours, and SBP in a cohort of elderly Chinese people.<br />Competing Interests: Conflict-of-interest statement: All the authors of this manuscript have no conflicts of interest to disclose.<br /> (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)

Details

Language :
English
ISSN :
2307-8960
Volume :
11
Issue :
29
Database :
MEDLINE
Journal :
World journal of clinical cases
Publication Type :
Academic Journal
Accession number :
37946770
Full Text :
https://doi.org/10.12998/wjcc.v11.i29.7004