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Expression of CD5 in salivary gland tumors: an ancillary marker for carcinoma showing thymus-like differentiation (CASTLE) of the major salivary gland.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 2024 Jun; Vol. 484 (6), pp. 945-950. Date of Electronic Publication: 2023 Nov 13. - Publication Year :
- 2024
-
Abstract
- Recently, cases of carcinoma showing thymus-like differentiation (CASTLE) occurring in major salivary glands have been identified. To assess the diagnostic value of CD5 immunohistochemistry in distinguishing salivary CASTLE from other types of salivary gland tumors, we evaluated CD5 expression in 109 salivary gland tumors, encompassing 23 different histological types, including salivary CASTLE. In addition, we reviewed 10 previously reported cases of salivary CASTLE. Most salivary CASTLE cases (10/11, 91%) showed strong CD5 expression. In contrast, 104 of 108 (96%) non-salivary CASTLE tumors were negative for CD5, while the remaining four tumors (3.7%), all of which were histologically Warthin tumors, showed focal positivity for CD5 with weak to moderate intensity. In conclusion, the findings in this study support the potential use of CD5 immunohistochemistry for distinguishing salivary CASTLE from other histological types of salivary gland tumors. Aberrant CD5 expression in this tumor may be linked to the tumor microenvironment.<br /> (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Humans
Female
Male
Middle Aged
Aged
Adult
Cell Differentiation
Diagnosis, Differential
Salivary Glands pathology
Salivary Glands metabolism
Carcinoma pathology
Carcinoma diagnosis
Carcinoma metabolism
Aged, 80 and over
Salivary Gland Neoplasms pathology
Salivary Gland Neoplasms diagnosis
Salivary Gland Neoplasms metabolism
CD5 Antigens metabolism
CD5 Antigens analysis
Biomarkers, Tumor analysis
Biomarkers, Tumor metabolism
Immunohistochemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2307
- Volume :
- 484
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 37953373
- Full Text :
- https://doi.org/10.1007/s00428-023-03701-8