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Molecular Mechanisms of Glaucoma Pathogenesis with Implications to Caveolin Adaptor Protein and Caveolin-Shp2 Axis.
- Source :
-
Aging and disease [Aging Dis] 2024 Oct 01; Vol. 15 (5), pp. 2051-2068. Date of Electronic Publication: 2024 Oct 01. - Publication Year :
- 2024
-
Abstract
- Glaucoma is a common retinal disorder characterized by progressive optic nerve damage, resulting in visual impairment and potential blindness. Elevated intraocular pressure (IOP) is a major risk factor, but some patients still experience disease progression despite IOP-lowering treatments. Genome-wide association studies have linked variations in the Caveolin1/2 (CAV-1/2) gene loci to glaucoma risk. Cav-1, a key protein in caveolae membrane invaginations, is involved in signaling pathways and its absence impairs retinal function. Recent research suggests that Cav-1 is implicated in modulating the BDNF/TrkB signaling pathway in retinal ganglion cells, which plays a critical role in retinal ganglion cell (RGC) health and protection against apoptosis. Understanding the interplay between these proteins could shed light on glaucoma pathogenesis and provide potential therapeutic targets.
- Subjects :
- Humans
Signal Transduction
Protein Tyrosine Phosphatase, Non-Receptor Type 11 metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 11 genetics
Retinal Ganglion Cells pathology
Retinal Ganglion Cells metabolism
Caveolin 2 metabolism
Caveolin 2 genetics
Animals
Brain-Derived Neurotrophic Factor metabolism
Brain-Derived Neurotrophic Factor genetics
Intraocular Pressure physiology
Receptor, trkB metabolism
Receptor, trkB genetics
Glaucoma metabolism
Glaucoma genetics
Glaucoma pathology
Caveolin 1 metabolism
Caveolin 1 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2152-5250
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Aging and disease
- Publication Type :
- Academic Journal
- Accession number :
- 37962455
- Full Text :
- https://doi.org/10.14336/AD.2023.1012