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Sonographic "Cervix Sign": A New Ancillary Sign of Gallbladder Neck Malignancy.

Authors :: Rana P
Pruthi H
Gupta P
Chhabra M
Soundararajan R
Singh S
Gulati A
Das CK
Yadav TD
Gupta V
Gupta P
Saikia UN
Dutta U
Sandhu M
Source :: Journal of clinical and experimental hepatology [J Clin Exp Hepatol] 2023 Nov-Dec; Vol. 13 (6), pp. 972-976. Date of Electronic Publication: 2023 May 30.
Publication Year :: 2023
Abstract: Background: The differentiation of benign and malignant gallbladder wall thickening is challenging. The purpose of this study is to evaluate a new sonographic sign, "cervix sign" for differentiation of benign and malignant gallbladder neck thickening.<br />Methods: This retrospective study comprised consecutive patients with gallbladder neck thickening who underwent sonography between August 2019 and December 2021. The presence of "cervix sign" was assessed by two radiologists independently.<br />Results: Sixty-five patients had gallbladder neck thickening (28 malignant and 37 benign). The sonographic "cervix sign" was present in 18 (64%) patients with malignant thickening and in only one (2.7%) patient with benign thickening ( P  = 0.0001). The mean wall thickness was greater, and symmetric wall thickening and liver metastases were more common in malignant thickening with "cervix sign" (without reaching statistical significance). There was substantial agreement (kappa = 0.78) between the two observers for the cervix sign.<br />Conclusion: Sonographic "cervix sign" is a useful ancillary feature of gallbladder neck cancer.<br /> (© 2023 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights reserved.)