Back to Search
Start Over
Antibiotic resistance of Helicobacter pylori in Chinese children: A multicenter study from 2016 to 2023.
- Source :
-
Helicobacter [Helicobacter] 2024 Jan-Feb; Vol. 29 (1), pp. e13038. Date of Electronic Publication: 2023 Nov 20. - Publication Year :
- 2024
-
Abstract
- Background: To investigate the antibiotic resistance of Helicobacter pylori (H. pylori) strains to clarithromycin, metronidazole, amoxicillin, levofloxacin, furazolidone, and tetracycline in Chinese children.<br />Materials and Methods: This multicenter, retrospective study was conducted from January 2016 through May 2023. Gastric mucosa biopsies were obtained from pediatric participants who underwent upper gastrointestinal endoscopy at 96 hospitals in northern, southwestern, and southeastern China. The susceptibility of H. pylori to six commonly used antibiotics was determined by agar dilution method.<br />Results: Among the 3074 H. pylori isolates, 36.7% were resistant to clarithromycin, 77.3% to metronidazole, 16.6% to levofloxacin, and 0.3% to amoxicillin. No strains were detected to be resistant to furazolidone or tetracycline. During the 8-year study period, resistance to clarithromycin and metronidazole showed a significant upward trend, while the resistance pattern of the other antibiotics demonstrated a slight but nonsignificant fluctuation. Significant regional differences were found in the distribution of clarithromycin resistance among the northern (66.0%), southwestern (48.2%), and southeastern (34.6%) regions. The metronidazole resistance rate was significantly lower in the southeastern coastal region (76.3%) than in the other two regions (88.2% in the north and 87.7% in the southwest). Multi-drug resistance for two or more antibiotics was detected in 36.3% of the H. pylori strains, and the predominant multi-resistance pattern was the dual resistance to clarithromycin and metronidazole.<br />Conclusions: The prevalence of H. pylori resistance to clarithromycin and metronidazole is rather high in Chinese children and has been increasing over time. A relatively high resistance rate to levofloxacin was also noticed in children, while almost all strains were susceptible to amoxicillin, furazolidone, and tetracycline. It will be of great clinical significance to continuously monitor the antibiotic-resistance patterns of H. pylori in the pediatric population.<br /> (© 2023 John Wiley & Sons Ltd.)
- Subjects :
- Child
Humans
Clarithromycin
Metronidazole pharmacology
Levofloxacin
Furazolidone
Retrospective Studies
Microbial Sensitivity Tests
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents therapeutic use
Amoxicillin pharmacology
Tetracycline
Drug Resistance, Microbial
China epidemiology
Drug Resistance, Bacterial
Helicobacter pylori
Helicobacter Infections epidemiology
Helicobacter Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1523-5378
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Helicobacter
- Publication Type :
- Academic Journal
- Accession number :
- 37983899
- Full Text :
- https://doi.org/10.1111/hel.13038