Back to Search
Start Over
Effects of diabetes mellitus on left ventricular function and deformation in patients with restrictive cardiomyopathies: a 3.0T CMR feature tracking study.
- Source :
-
Cardiovascular diabetology [Cardiovasc Diabetol] 2023 Nov 20; Vol. 22 (1), pp. 317. Date of Electronic Publication: 2023 Nov 20. - Publication Year :
- 2023
-
Abstract
- Background: Diabetes mellitus (DM) is the most common metabolic disease worldwide and a major risk factor for adverse cardiovascular events, while the additive effects of DM on left ventricular (LV) deformation in the restrictive cardiomyopathy (RCM) cohort remain unclear. Accordingly, we aimed to investigate the additive effects of DM on LV deformation in patients with RCM.<br />Materials and Methods: One hundred thirty-six RCM patients without DM [RCM(DM-)], 46 with DM [RCM (DM+)], and 66 age- and sex-matched control subjects who underwent cardiac magnetic resonance (CMR) scanning were included. LV function, late gadolinium enhancement (LGE) type, and LV global peak strains (including radial, circumferential, and longitudinal directions) were measured. The determinant of reduced LV global myocardial strain for all RCM patients was assessed using multivariable linear regression analyses. The receiver operating characteristic curve (ROC) was performed to illustrate the relationship between DM and decreased LV deformation.<br />Results: Compared with the control group, RCM (DM-) and RCM(DM+) patients presented increased LV end-diastolic index and end-systolic volume index and decreased LV ejection fraction. LV GPS in all three directions and longitudinal PDSR progressively declined from the control group to the RCM(DM-) group to the RCM(DM+) group (all p < 0.05). DM was an independent determinant of impaired LV GPS in the radial, circumferential, and longitudinal directions and longitudinal PDSR (β = - 0.217, 0.176, 0.253, and - 0.263, all p < 0.05) in RCM patients. The multiparameter combination, including DM, showed an AUC of 0.81(95% CI 0.75-0.87) to predict decreased LV GLPS and an AUC of 0.69 (95% CI 0.62-0.76) to predict decreased LV longitudinal PDSR.<br />Conclusions: DM may have an additive deleterious effect on LV dysfunction in patients with RCM, especially diastolic dysfunction in RCM patients, indicating the importance of early identification and initiation of treatment of DM in patients with RCM.<br /> (© 2023. The Author(s).)
- Subjects :
- Humans
Ventricular Function, Left
Contrast Media
Gadolinium
Stroke Volume
Magnetic Resonance Imaging, Cine adverse effects
Cardiomyopathy, Restrictive complications
Ventricular Dysfunction, Left diagnostic imaging
Ventricular Dysfunction, Left etiology
Diabetes Mellitus diagnosis
Cardiomyopathies
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2840
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 37985989
- Full Text :
- https://doi.org/10.1186/s12933-023-02033-w