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Resveratrol Reduces Neuroinflammation and Hippocampal Microglia Activation and Protects Against Impairment of Memory and Anxiety-Like Behavior in Experimental Cerebral Palsy.
- Source :
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Molecular neurobiology [Mol Neurobiol] 2024 Jun; Vol. 61 (6), pp. 3619-3640. Date of Electronic Publication: 2023 Nov 25. - Publication Year :
- 2024
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Abstract
- Cerebral palsy (CP) is a neurodevelopmental disorder characterized by motor and postural impairments. However, early brain injury can promote deleterious effects on the hippocampus, impairing memory. This study aims to investigate the effects of resveratrol treatment on memory, anxiety-like behavior, and neuroinflammation markers in rats with CP. Male Wistar rats were subjected to perinatal anoxia (P0-P1) and sensory-motor restriction (P2-P28). They were treated with resveratrol (10 mg/kg, 0.1 ml/100 g) or saline from P3-P21, being divided into four experimental groups: CS (n = 15), CR (n = 15), CPS (n = 15), and CPR (n = 15). They were evaluated in the tests of novel object recognition (NORT), T-Maze, Light-Dark Box (LDB), and Elevated Plus Maze (EPM). Compared to the CS group, the CPS group has demonstrated a reduced discrimination index on the NORT (p < 0.0001) and alternation on the T-Maze (p < 0.01). In addition, the CPS group showed an increase in permanence time on the dark side in LDB (p < 0.0001) and on the close arms of the EPM (p < 0.001). The CPR group demonstrated an increase in the object discrimination index (p < 0.001), on the alternation (p < 0.001), on the permanence time on the light side (p < 0.0001), and on the open arms (p < 0.001). The CPR group showed a reduction in gene expression of IL-6 (p = 0.0175) and TNF-α (p = 0.0007) and an increase in Creb-1 levels (p = 0.0020). The CPS group showed an increase in the activated microglia and a reduction in cell proliferation in the hippocampus, while CPR animals showed a reduction of activated microglia and an increase in cell proliferation. These results demonstrate promising effects of resveratrol in cerebral palsy behavior impairment through reduced neuroinflammation in the hippocampus.<br /> (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Animals
Male
Neuroinflammatory Diseases drug therapy
Neuroinflammatory Diseases pathology
Rats
Behavior, Animal drug effects
Inflammation pathology
Memory drug effects
Maze Learning drug effects
Resveratrol pharmacology
Resveratrol therapeutic use
Rats, Wistar
Anxiety drug therapy
Hippocampus drug effects
Hippocampus pathology
Hippocampus metabolism
Microglia drug effects
Microglia metabolism
Microglia pathology
Cerebral Palsy pathology
Cerebral Palsy drug therapy
Memory Disorders drug therapy
Memory Disorders pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1559-1182
- Volume :
- 61
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Molecular neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 38001357
- Full Text :
- https://doi.org/10.1007/s12035-023-03772-3