Back to Search
Start Over
Immunomodulatory actions of myeloid-derived suppressor cells in the context of innate immunity.
- Source :
-
Innate immunity [Innate Immun] 2024 Jan; Vol. 30 (1), pp. 2-10. Date of Electronic Publication: 2023 Nov 28. - Publication Year :
- 2024
-
Abstract
- Myeloid-derived suppressor cells (MDSCs) are notable innate immune cells, which are further divided into two subpopulations, i.e., monocytic and granulocytic. These cells are traditionally considered to mainly suppress the T-cell responses. However, more updated data indicate that their properties are rather immunomodulatory than solely immunosuppressive. Indeed, MDSCs display extensive crosstalk with other either innate or adaptive immune cells, and, according to the situation under which they are triggered, they may enhance or attenuate the immune response. However, their positive role in host's defense mechanisms under specific conditions is rarely discussed in the literature. In this mini-review, the authors briefly summarise the mechanisms of action of MDSCs under distinct conditions, such as infections and malignancies, with a particular emphasis on their role as components of the innate immunity system.<br />Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Details
- Language :
- English
- ISSN :
- 1753-4267
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Innate immunity
- Publication Type :
- Academic Journal
- Accession number :
- 38018014
- Full Text :
- https://doi.org/10.1177/17534259231215581