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High-grade intraductal carcinoma of the parotid gland harboring CTNNA1::ALK rearrangement: Changes in genetic status using genetic testing during treatment with an ALK inhibitor.
- Source :
-
Head & neck [Head Neck] 2024 Mar; Vol. 46 (3), pp. E26-E31. Date of Electronic Publication: 2023 Nov 29. - Publication Year :
- 2024
-
Abstract
- Background: Salivary gland carcinomas harboring anaplastic lymphoma kinase (ALK) rearrangements are rare. Here, we present the pathological characteristics, clinical course, and changes in the genetic status of a salivary gland carcinoma harboring a catenin alpha 1 (CTNNA1)::ALK rearrangement during treatment with an ALK tyrosine kinase inhibitor (TKI).<br />Methods: A 59-year-old man with a parotid tumor and cervical lymph node metastases underwent total parotidectomy and radical neck dissection. One month after completion of postoperative radiotherapy, the patient experienced multiple recurrences.<br />Results: Subsequent treatment with the ALK-TKI alectinib was initially effective against the intraductal carcinoma harboring CTNNA1::ALK rearrangement and TP53 mutation. However, 10 months later the patients' condition deteriorated, and an additional phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutation was detected. The patient ultimately succumbed to multiple organ failure.<br />Conclusion: The clinical course suggested the concurrent emergence of TP53 and PIK3CA mutations and ALK-TKI drug-selective growth of non-ALK rearrangement gene tumor cells.<br /> (© 2023 Wiley Periodicals LLC.)
- Subjects :
- Male
Humans
Middle Aged
Anaplastic Lymphoma Kinase genetics
Anaplastic Lymphoma Kinase therapeutic use
Parotid Gland pathology
Protein Kinase Inhibitors therapeutic use
Protein-Tyrosine Kinases
Mutation
Genetic Testing
Disease Progression
alpha Catenin genetics
Lung Neoplasms pathology
Carcinoma, Intraductal, Noninfiltrating drug therapy
Carcinoma, Intraductal, Noninfiltrating genetics
Salivary Gland Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Report
- Accession number :
- 38018800
- Full Text :
- https://doi.org/10.1002/hed.27587