Impact of periprocedural myocardial injury after transcatheter aortic valve implantation on long-term mortality: a meta-analysis of Kaplan-Meier derived individual patient data.

Background: Periprocedural myocardial injury (PPMI) frequently occurs after transcatheter aortic valve implantation (TAVI), although its impact on long-term mortality is uncertain.
Methods: We performed a pooled analysis of Kaplan-Meier-derived individual patient data to compare survival in patients with and without PPMI after TAVI. Flexible parametric models with B-splines and landmark analyses were used to determine PPMI prognostic value. Subgroup analyses for VARC-2, troponin, and creatine kinase-MB (CK-MB)-defined PPMI were also performed.
Results: Eighteen observational studies comprising 10,094 subjects were included. PPMI was associated with lower overall survival (OS) after two years (HR = 1.46, 95% CI 1.30-1.65, p  < 0.01). This was also observed when restricting the analysis to overall VARC-2-defined PPMI (HR = 1.23, 95% CI 1.07-1.40, p  < 0.01). For VARC-2 PPMI criteria and VARC-2 troponin-only, higher mortality was restricted to the first 2 months after TAVI (HR = 1.64, 95% CI 1.31-2.07, p  < 0.01; and HR = 1.32, 95% CI 1.05-1.67, p  = 0.02, respectively), while for VARC-2 defined CK-MB-only the increase in mortality was confined to the first 30 days (HR = 7.44, 95% CI 4.76-11.66, p  < 0.01).
Conclusion: PPMI following TAVI was associated with lower overall survival compared with patients without PPMI. PPMI prognostic impact is restricted to the initial months after the procedure. The analyses were consistent for VARC-2 criteria and for both biomarkers, yet CK-MB was a stronger prognostic marker of mortality than troponin.
Competing Interests: FB is proctor for Edwards Lifesciences, Medtronic and Boston Scientific Scientific and received research grant from Medtronic. JR has received institutional research grants and speaker/consultant fees from Edwards Lifesciences and Medtronic. NV has received grants from Abbott, Boston Scientific, Biotronik, Edwards Lifesciences, Medtronic, Pulsecath BV, Abiomed, Daiichi Sankyo; consulting fees from: Jenavalve, Daiichi Sankyo, Abbott, Boston Scientific, Medtronic; payment or honoraria for lectures, presentations, speakers, manuscripts and educational events from Abiomed, Amgen and support for attending meetings and or travel from Jenavalve. AA is proctor for Boston Scientific and has received research grant from Medtronic. HR is proctor for Edwards Lifesciences, Medtronic and Boston Scientific and received research grant from Medtronic. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(© 2023 de Sá Marchi, Calomeni, Gauza, Kanhouche, Ravani, Rodrigues, Tarasoutchi, de Brito, Rodés-Cabau, Van Mieghem, Abizaid and Ribeiro.)