Long-term prognostic value of [ 15 O]H 2 O PET imaging in patients suspected for cerebral hemodynamic insufficiency.

Objectives: Quantitative regional cerebral perfusion (rCBF) measurements using [ ¹⁵ O]H ₂ O PET with arterial cannulation and acetazolamide (ACZ) challenge have been reserved to identify high-risk patients that are candidates for by-pass operation. We aimed to assess the prognostic value of various parameters in quantitative [ ¹⁵ O]H ₂ O PET measurements in patients not subsequently undergoing surgery.
Methods: We identified 32 eligible patients who underwent [ ¹⁵ O]H ₂ O brain PET imaging for suspicion of hemodynamic insufficiency between 2009 and 2020. Cerebrovascular events were defined as new ischemic lesions on MRI, stroke, transient ischemic attack, vascular dementia. Follow-up period was 91 months (range: 26-146). rCBF before (rCBF _base ) and after (rCBF _acz ) ACZ challenge and the relative increase (CVR), were examined in the anterior (ACA), middle (MCA), and posterior (PCA) cerebral artery territories of the affected hemisphere, and the most recent MRI scans were scored for infarcts and white matter lesions.
Results: Receiver operating characteristic (ROC) curve analysis showed higher prognostic accuracy for rCBF _acz (AUC:0.82) compared to CVR (AUC:0.72) and rCBF _base (AUC:0.77). ROC AUC, optimal thresholds (and corresponding sensitivity/specificity/accuracy) for rCBF _acz after ACZ in individual territories were 0.79 and 37.8 mL 100g ^-1 min ^-1 (0.81/0.63/0.72) for the ACA, 0.84 and 32 mL 100g ^-1 min ^-1 (0.81/0.75/0.78) for the MCA, and 0.70 and 43.9 ml/(mL 100g ^-1 min ^-1 (0.81/0.43/0,62) for the PCA. Kaplan Meier survival curve showed longer event-free survival in patients with rCBF _acz below cut-off (p=0.007). In multivariate analysis rCBF _acz remained a significant predictor when correcting for age.
Conclusion: Quantitative rCBF measurements after ACZ challenge with [ ¹⁵ O]H ₂ O PET provided high prognostic value for future cerebrovascular events.
Competing Interests: Declaration of Competing Interest None of the authors declare any conflicts of interest.
(Copyright © 2023. Published by Elsevier Inc.)