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Towards standardized human platelet lysate production in Europe: An initiative of the European Blood Alliance.

Towards standardized human platelet lysate production in Europe: An initiative of the European Blood Alliance.

Authors :
De Korte D
Delabie W
Feys HB
Klei T
Larsen R
Sigurjónsson Ó
Sousa AP
Source :
Vox sanguinis [Vox Sang] 2024 Jan; Vol. 119 (1), pp. 79-87. Date of Electronic Publication: 2023 Dec 04.
Publication Year :
2024

Abstract

Human platelet lysate (hPL) is a supplement for cell culture media that can be derived from platelet concentrates. As not-for-profit blood establishments, we endorse the evolution of maximally exploiting the potential of donated blood and its derived components, including platelets. The decision to use platelet concentrates to supply hPL as a cell culture supplement should align with the principles and values that blood establishments hold towards the use of donated blood components in transfusion. As a consequence, questions on ethics, practical standardization of hPL production and logistics as well as on assuring hPL quality and safety need careful consideration. We therefore propose an opinion on some of these matters based on available literature and on discussions within the proceedings of the Working Group on Innovation and New Products of the European Blood Alliance. In addition, we propose collaboration among European blood establishments to streamline efforts of hPL supply to maximize the potential of hPL and its application in the wider field of medicine.<br /> (© 2023 International Society of Blood Transfusion.)

Details

Language :
English
ISSN :
1423-0410
Volume :
119
Issue :
1
Database :
MEDLINE
Journal :
Vox sanguinis
Publication Type :
Academic Journal
Accession number :
38049931
Full Text :
https://doi.org/10.1111/vox.13562