Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan.

Authors :: Lin YT
Chuang C
Chou SH
Juan CH
Yang TC
Kreiswirth BN
Chen L
Source :: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2024 Feb; Vol. 43 (2), pp. 389-393. Date of Electronic Publication: 2023 Dec 07.
Publication Year :: 2024
Abstract: The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes (iroBCDN, iucABCD, rmpA, rmpA2, and iutA), while KP2683-1 acquired an IncL type plasmid harboring bla <subscript>OXA-48</subscript> .<br /> (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Subjects :: Humans
Klebsiella pneumoniae
Taiwan epidemiology
Abscess
Plasmids genetics
Anti-Bacterial Agents pharmacology
beta-Lactamases genetics
Klebsiella Infections epidemiology
Klebsiella Infections microbiology

Language :: English
ISSN :: 1435-4373
Volume :: 43
Issue :: 2
Database :: MEDLINE
Journal :: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Publication Type :: Academic Journal
Accession number :: 38062176
Full Text :: https://doi.org/10.1007/s10096-023-04733-3

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