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Rapid HIV-1 genotyping assay for the detection of capsid mutations.
- Source :
-
Journal of medical virology [J Med Virol] 2023 Dec; Vol. 95 (12), pp. e29292. - Publication Year :
- 2023
-
Abstract
- Human immunodeficiency virus (HIV) capsid is one of the most recent viral proteins successfully targeted for the development of antiretrovirals. Lenacapavir is a first in class HIV-1 capsid inhibitor that was recently approved for the treatment of highly treatment-experienced people with HIV in combination with other anti-HIV drugs. Owing to the novelty of the viral target, methods to characterize the potential resistance-associated mutations present in capsid upon treatment failure have not been fully established yet. Here, we describe a rapid and simple method to amplify capsid fragments and to determine their sequence from various clinical samples including diverse HIV-1 subtypes. These methods could easily be implemented in laboratories, including hospital laboratories often caring for this patient population.<br /> (© 2023 Gilead Sciences, Inc. Journal of Medical Virology published by Wiley Periodicals LLC.)
Details
- Language :
- English
- ISSN :
- 1096-9071
- Volume :
- 95
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of medical virology
- Publication Type :
- Academic Journal
- Accession number :
- 38063404
- Full Text :
- https://doi.org/10.1002/jmv.29292