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Structure of Transmembrane AMPA Receptor Regulatory Protein Subunit γ2.
- Source :
-
BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 28. Date of Electronic Publication: 2023 Nov 28. - Publication Year :
- 2023
-
Abstract
- Transmembrane AMPA receptor regulatory proteins (TARPs) are claudin-like proteins that tightly regulate AMPA receptors (AMPARs) and are fundamental for excitatory neurotransmission. We used cryo-electron microscopy (cryo-EM) to reconstruct the 36 kDa TARP subunit γ2 to 2.3 Å and reveal the structural diversity of TARPs. Our data reveals critical motifs that distinguish TARPs from claudins and define how sequence variations within TARPs differentiate subfamilies and their regulation of AMPARs.<br />Competing Interests: Conflict of Interest R.L.H. is scientific cofounder and Scientific Advisory Board (SAB) member of Neumora Therapeutics and SAB member of MAZE Therapeutics.
Details
- Language :
- English
- Database :
- MEDLINE
- Journal :
- BioRxiv : the preprint server for biology
- Accession number :
- 38076787
- Full Text :
- https://doi.org/10.1101/2023.11.28.569079