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CSF cytology of common primary CNS neoplasms categorized by CNS WHO 2021.
- Source :
-
Cytopathology : official journal of the British Society for Clinical Cytology [Cytopathology] 2024 Sep; Vol. 35 (5), pp. 608-615. Date of Electronic Publication: 2023 Dec 11. - Publication Year :
- 2024
-
Abstract
- Objective: The detection of neoplastic cells in cerebral spinal fluid (CSF) is pivotal for the management of patients with central nervous system (CNS) tumours. This article delves into the CSF cytological characteristics of common CNS neoplasms, aligning with the 2021 World Health Organization (WHO) classification of CNS tumours.<br />Methods: A retrospective review of CSF specimens positive for primary CNS neoplasms was performed at three tertiary medical centres. Only cases that had histopathologic confirmation and/or molecular workup were included.<br />Results: Common primary CNS neoplasms seen in CSF cytology specimens include medulloblastoma, (non-WNT/non-SHH as well as SHH-activated and TP53 mutant), pineoblastoma, atypical teratoid/rhabdoid tumour (AT/RT), IDH-wildtype glioblastoma, and primary diffuse large B-cell lymphoma of the CNS. Ependymomas and germinomas can also have CSF involvement but are less common. Although the typical histologic architecture of these tumours may not be preserved in the CSF, unique cytomorphologic features such as nuclear moulding, nuclear pleomorphism, rhabdoid cells, prominent nucleoli and rosette formation can still be appreciated.<br />Conclusion: Adopting the updated terminology and correlating cytologic observations with molecular findings will streamline the diagnostic process, reducing the complexities and ambiguities pathologists often encounter when analysing CSF specimens for potential primary CNS neoplasms.<br /> (© 2023 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Female
Humans
Male
Cerebrospinal Fluid cytology
Ependymoma pathology
Ependymoma cerebrospinal fluid
Ependymoma diagnosis
Glioblastoma pathology
Glioblastoma diagnosis
Glioblastoma cerebrospinal fluid
Lymphoma, Large B-Cell, Diffuse pathology
Lymphoma, Large B-Cell, Diffuse cerebrospinal fluid
Lymphoma, Large B-Cell, Diffuse diagnosis
Medulloblastoma pathology
Medulloblastoma cerebrospinal fluid
Medulloblastoma diagnosis
Medulloblastoma classification
Pinealoma pathology
Pinealoma diagnosis
Pinealoma cerebrospinal fluid
Retrospective Studies
Rhabdoid Tumor pathology
Rhabdoid Tumor cerebrospinal fluid
Rhabdoid Tumor diagnosis
Teratoma pathology
Teratoma diagnosis
Teratoma cerebrospinal fluid
Central Nervous System Neoplasms pathology
Central Nervous System Neoplasms cerebrospinal fluid
Central Nervous System Neoplasms diagnosis
Cytodiagnosis methods
World Health Organization
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2303
- Volume :
- 35
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cytopathology : official journal of the British Society for Clinical Cytology
- Publication Type :
- Academic Journal
- Accession number :
- 38078513
- Full Text :
- https://doi.org/10.1111/cyt.13340