Back to Search
Start Over
Gliclazide Ameliorates Neuronal Injury by Attenuating Oxidative Stress in D-gal-Induced Senescent Cells and Aging Mice.
- Source :
-
Molecular neurobiology [Mol Neurobiol] 2024 Jul; Vol. 61 (7), pp. 4391-4401. Date of Electronic Publication: 2023 Dec 13. - Publication Year :
- 2024
-
Abstract
- Enhancement of oxidative stress and resultant neuronal injury play important roles in initiating cognitive impairment during the aging process. Thus, attenuating oxidative injury is regarded as a profitable therapeutic strategy for age-associated cognitive impairment. Previous studies showed that gliclazide (Gli) had a protective role in neuronal injury from cerebral ischemia/reperfusion (I/R) injury. However, whether Gli has a profitable effect on age-associated cognitive impairment remains largely unclear. The present study showed that Gli held the potential to attenuate neuronal apoptosis in D-gal-induced senescent cells and aging mice. Additionally, Gli could alleviate synaptic injury and cognitive function in D-gal-induced aging mice. Further study showed that Gli could attenuate oxidative stress in D-gal-induced senescent cells and aging mice. The p38 MAPK pathway was predicted as the downstream target of Gli retarding oxidative stress using in silico analysis. Further studies revealed that Gli attenuated D-gal-induced phosphorylation of p38 and facilitated Nrf2 nuclear expression, indicating that the anti-oxidative property of Gli may be associated with the p38 MAPK pathway. The study demonstrates that Gli has a beneficial effect on ameliorating D-gal-induced neuronal injury and cognitive impairment, making this compound a promising agent for the prevention and treatment of age-associated cognitive impairment.<br /> (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Animals
Male
Mice
Mice, Inbred C57BL
p38 Mitogen-Activated Protein Kinases metabolism
Galactose pharmacology
Apoptosis drug effects
NF-E2-Related Factor 2 metabolism
Oxidative Stress drug effects
Aging drug effects
Aging pathology
Aging metabolism
Cellular Senescence drug effects
Gliclazide pharmacology
Neurons drug effects
Neurons metabolism
Neurons pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1559-1182
- Volume :
- 61
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Molecular neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 38087171
- Full Text :
- https://doi.org/10.1007/s12035-023-03850-6