Glycosides from the leaves of Fraxinus Hubeiensis.

Authors :: Liu XY
Tang HX
Sheng WB
Luo QJ
Mao LX
Yang YP
Guo XZ
Wu QL
Jian YQ
Wang W
Zhou XD
Source :: BMC chemistry [BMC Chem] 2023 Dec 13; Vol. 17 (1), pp. 182. Date of Electronic Publication: 2023 Dec 13.
Publication Year :: 2023
Abstract: Fraxinus hubeiensis is a plant endemic to China and widely used as folk medicine to treat various diseases. However, its chemical constituents have never been reported sufficiently. Thus, the primary objective of this study was to investigate the phytochemical constituents and biological activities of F. hubeiensis leaves. Hence, combined column chromatographic and spectroscopic techniques were used to identify and characterize the secondary metabolites such as a pair of 3-keto-glycoside epimers (1) and (2), along with five known compounds (3 ~ 7). The results of α-glucosidase inhibitory activity exhibited that 1 and 2 had moderate activity with IC <subscript>50</subscript> values of 359.50 and 468.43 µM, respectively, compared to a positive control acarbose with the IC <subscript>50</subscript> value of 164.08 µM. However, Compounds 1-6 were shown to be inactive against the tested microbes.<br /> (© 2023. The Author(s).)