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Prospective results for 5-year survival and toxicity of moderately hypofractionated radiotherapy with simultaneous integrated boost (SIB) in (very) high-risk prostate cancer.
- Source :
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Clinical and translational radiation oncology [Clin Transl Radiat Oncol] 2023 Nov 17; Vol. 44, pp. 100702. Date of Electronic Publication: 2023 Nov 17 (Print Publication: 2024). - Publication Year :
- 2023
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Abstract
- Purpose: High-risk (HR) prostate cancer patients usually receive high-dose radiotherapy (RT) using a two-phase sequential technique, but data on a simultaneous integrated boost (SIB) technique are lacking. We prospectively evaluated the long-term results of urinary (GU) and digestive (GI) toxicity and survival data for high-dose RT using a SIB technique in HR and very high-risk (VHR) prostate cancer.<br />Methods: Patients were treated using an SIB technique in 34 fractions, at a dose of 54.4 Gy to the pelvis and seminal vesicles and 74.8 Gy to the prostate, combined with 36 months of androgen-depriving therapy in a prospective multicenter study. Acute and late GU and GI toxicity data were collected. Overall survival (OS), biochemical-relapse-free survival (bRFS), loco-regional-relapse-free survival (LRRFS), metastasis-free-survival (MFS) and disease-free-survival (DFS) were assessed.<br />Results: We recruited 114 patients. After a median follow-up of 62 months, very few patients experienced acute (M0-M3) (G3-4 GU = 3.7 %; G3-4 GI = 0.9 %) or late (M6-M60) severe toxicity (G3-4 GU = 5.6 %; G3-4 GI = 2.8 %). The occurrence of acute G2 + GU or GI toxicity was significantly related to the consequential late G2 + toxicity (p < 0.01 for both GU and GI). Medians of OS, bRFS, LRRFS, MFS and DFS were not reached. At 60 months, OS, bRFS, LRRFS, MFS and DFS were 88.2 % [82.1; 94.7], 86.0 % [79.4 %;93.2 %], 95.8 % [91.8 %;99.9 %], 87.2 % [80.9 %;94.0 %] and 84.1 % [77.2 %;91.6 %] respectively.<br />Conclusion: SIB RT at a dose of 54.4 Gy to the pelvis and 74.8 Gy to the prostate is feasible, leading to satisfying tumor control and reasonable toxicity in HR and VHR prostate cancer.<br />Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: IM, LL, MAM, PP, NMN, PG, DP, BC, PD, NS, GN, JK, IL, CGC, SS: none. DA declares conflicts of interest with Novagray, which has nothing to do with this study.<br /> (© 2023 The Authors.)
Details
- Language :
- English
- ISSN :
- 2405-6308
- Volume :
- 44
- Database :
- MEDLINE
- Journal :
- Clinical and translational radiation oncology
- Publication Type :
- Academic Journal
- Accession number :
- 38111609
- Full Text :
- https://doi.org/10.1016/j.ctro.2023.100702