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Improved medication adherence in COPD patients using tiotropium or tiotropium olodaterol with the HealthPrize digital behavior change program.
- Source :
-
Expert review of pharmacoeconomics & outcomes research [Expert Rev Pharmacoecon Outcomes Res] 2024 Sep; Vol. 24 (7), pp. 829-843. Date of Electronic Publication: 2024 Jan 04. - Publication Year :
- 2024
-
Abstract
- Objective: To assess the impact of the HealthPrize RespiPoints™ program on treatment adherence and persistence in adults with chronic obstructive pulmonary disease (COPD).<br />Methods: In this retrospective cohort study, program participants and nonparticipants receiving tiotropium bromide (TIO) or TIO and olodaterol between 1 January 2015-31 March 2020 were propensity score matched (PSM), from the linked database of the HealthPrize patient list and IQVIA PharMetrics® Plus. Treatment adherence, persistence, healthcare resource utilization, and costs were compared. Multivariable logistic regression models assessed the odds of adherence (≥80% proportion of days covered [PDC]), adjusted risk of discontinuation, and adjusted total healthcare costs.<br />Results: Program participants ( n = 262) demonstrated a 44% greater adherence during followup than nonparticipants ( n = 262) (mean [standard deviation] PDC: 0.72 [0.27] vs 0.50 [0.36], p < 0.0001). Participants had higher odds of adherence vs nonparticipants (adjusted odds ratio: 2.51; 95% confidence interval: 1.72-3.66, p < 0.0001) and a lower percentage of participants discontinued their index medication (19.85% vs 33.59%, p = 0.0004). Fewer participants were hospitalized during follow-up (13.74% vs 17.56%, p = 0.23); adjusted total medical costs were 24% lower ( p = 0.08). Higher pharmacy costs partially offset lower healthcare costs.<br />Conclusions: Program participants showed improved COPD medication adherence and persistence compared to nonparticipants.
- Subjects :
- Humans
Male
Retrospective Studies
Female
Middle Aged
Aged
Cohort Studies
Benzoxazines administration & dosage
Benzoxazines economics
Health Care Costs statistics & numerical data
Drug Combinations
Administration, Inhalation
Follow-Up Studies
Pulmonary Disease, Chronic Obstructive drug therapy
Pulmonary Disease, Chronic Obstructive economics
Tiotropium Bromide administration & dosage
Medication Adherence statistics & numerical data
Bronchodilator Agents administration & dosage
Bronchodilator Agents economics
Bronchodilator Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8379
- Volume :
- 24
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Expert review of pharmacoeconomics & outcomes research
- Publication Type :
- Academic Journal
- Accession number :
- 38116664
- Full Text :
- https://doi.org/10.1080/14737167.2023.2296561