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Associations of long-term exposure to air pollution and physical activity with the risk of systemic inflammation-induced multimorbidity in Chinese adults: results from the China multi-ethnic cohort study (CMEC).
- Source :
-
BMC public health [BMC Public Health] 2023 Dec 21; Vol. 23 (1), pp. 2556. Date of Electronic Publication: 2023 Dec 21. - Publication Year :
- 2023
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Abstract
- Objective: Previous studies proved the effect of long-term exposure to air pollution or physical activity (PA) on the risk of systemic inflammation-induced multimorbidity (SIIM), while the evidence regarding their joint effects was rare, especially in low- and middle-income countries. Therefore, we aimed to examine the extent of interaction or joint relations of PA and air pollution with SIIM.<br />Methods: This study included 72,172 participants from China Multi-Ethnic Cohort.The average concentrations of ambient particulate matter pollutants (PM <subscript>1</subscript> , PM <subscript>2.5</subscript> , and PM <subscript>10</subscript> ) were estimated using satellite-based random forest models. Self-reported information on a range of physical activities related to occupation, housework, commuting, and leisure activities was collected by an interviewer-administered questionnaire. A total of 11 chronic inflammatory systemic diseases were assessed based on self-reported lifetime diagnosis or medical examinations. SIIM was defined as having ≥ 2 chronic diseases related to systemic inflammation. Logistic regression models were used to assess the complex associations of air pollution particulate matter and PA with SIIM.<br />Results: We found positive associations between long-term air pollution particulates exposure and SIIM, with odds ratios (95%CI) of 1.07 (1.03 to 1.11), 1.18 (1.13 to 1.24), and 1.08 (1.05 to 1.12) per 10 µg/m <superscript>3</superscript> increase in PM <subscript>1</subscript> , PM <subscript>2.5</subscript> , and PM <subscript>10</subscript> . No significant multiplicative interaction was found between ambient air pollutant exposure and PA on SIIM, whereas negative additive interaction was observed between long-term exposure to PM <subscript>2.5</subscript> and PA on SIIM. The positive associations between low volume PA and SIIM were stronger among those exposed to high-level air pollution particulates. Compared with individuals engaged in high volume PA and exposed to low-level ambient air pollutants, those engaged in low volume PA and exposed to high-level ambient air pollutants had a higher risk of SIIM (OR = 1.49 in PM <subscript>1</subscript> exposure, OR = 1.84 in PM <subscript>2.5</subscript> exposure, OR = 1.19 in PM <subscript>10</subscript> exposure).<br />Conclusions: Long-term (3 years average) exposure to PM <subscript>1</subscript> , PM <subscript>2.5</subscript> , and PM <subscript>10</subscript> was associated with an increased risk of SIIM. The associations were modified by PA, highlighting PA's importance in reducing SIIM for all people, especially those living in high-level air pollution regions.<br /> (© 2023. The Author(s).)
- Subjects :
- Adult
Humans
Cohort Studies
Multimorbidity
Environmental Exposure adverse effects
Environmental Exposure analysis
Particulate Matter adverse effects
Particulate Matter analysis
Inflammation epidemiology
Dust
China epidemiology
Exercise
Nitrogen Dioxide analysis
Air Pollution analysis
Air Pollutants adverse effects
Air Pollutants analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2458
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC public health
- Publication Type :
- Academic Journal
- Accession number :
- 38129832
- Full Text :
- https://doi.org/10.1186/s12889-023-17518-2