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The impact of ulinastatin on wound infection and healing in patients with burn wounds: A meta-analysis.
- Source :
-
International wound journal [Int Wound J] 2024 Apr; Vol. 21 (4), pp. e14562. Date of Electronic Publication: 2023 Dec 21. - Publication Year :
- 2024
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Abstract
- Burn injuries result in localised tissue damage and precipitate systemic responses; routine clinical treatments, which typically include metabolic nutritional support and anti-infection therapies, do not yield optimal outcomes. Therefore, we aimed to systematically evaluate the effects of ulinastatin on wound infection and healing in patients with burns to provide reliable evidence-based recommendations for burn treatment. An electronic search of the Web of Science, PubMed, Cochrane Library, Embase, Wanfang, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure databases, supplemented by manual searches, was conducted from database inception to October 2023 to collect randomised controlled trials (RCTs) assessing the efficacy of ulinastatin for the treatment of burns. Two researchers screened all retrieved articles according to the inclusion and exclusion criteria; the included studies were evaluated for quality, and the relevant data were extracted. Stata 17.0 software was employed for data analysis. Overall, 8 RCTs with 803 patients were included, with 404 and 399 in the ulinastatin and conventional treatment groups, respectively. The analysis revealed that wound infections (odds ratio [OR] = 0.08, 95% CI: 0.02-0.35, p = 0.001) and complications (OR = 0.21, 95% CI: 0.10-0.42, p < 0.001) were significantly lower, and wound healing time (standardised mean differences [SMD] = -1.31, 95% CI: -2.05 to -0.57, p = 0.001) was significantly shorter, in the ulinastatin groups than in the control group. This meta-analysis revealed that ulinastatin can effectively reduce the incidence of wound infections and complications and significantly shorten the duration of wound healing in patients with burns, thereby promoting early recovery in these patients.<br /> (© 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.)
- Subjects :
- Humans
Randomized Controlled Trials as Topic
Male
Female
Adult
Middle Aged
Trypsin Inhibitors therapeutic use
Burns drug therapy
Burns complications
Wound Healing drug effects
Wound Infection drug therapy
Wound Infection prevention & control
Glycoproteins therapeutic use
Glycoproteins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1742-481X
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International wound journal
- Publication Type :
- Academic Journal
- Accession number :
- 38130102
- Full Text :
- https://doi.org/10.1111/iwj.14562