SET protein as an epigenetics target.

Authors :: Silva GD
Milan TM
Chagas PS
Trevisan GL
Ferraz CL
Leopoldino AM
Source :: Epigenomics [Epigenomics] 2024 Feb; Vol. 16 (4), pp. 249-257. Date of Electronic Publication: 2023 Dec 22.
Publication Year :: 2024
Abstract: The SET gene has four transcripts reported in NCBI, coding two isoforms of SET proteins. The most known function of SET protein is inhibiting protein phosphatase 2A, a tumor suppressor, which has been associated with different biological processes. In this review, our focus was on exploring the other SET functions related to epigenetic mechanisms, which impact cellular migration, cell cycle and apoptosis.