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Nanoscale Covalent Organic Framework with Staggered Stacking of Phthalocyanines for Mitochondria-Targeted Photodynamic Therapy.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2024 Jan 10; Vol. 146 (1), pp. 849-857. Date of Electronic Publication: 2023 Dec 22. - Publication Year :
- 2024
-
Abstract
- Phthalocyanine photosensitizers (PSs) have shown promise in fluorescence imaging and photodynamic therapy (PDT) of malignant tumors, but their practical application is limited by the aggregation-induced quenching (AIQ) and inherent photobleaching of PSs. Herein, we report the synthesis of a two-dimensional nanoscale covalent organic framework (nCOF) with staggered (AB) stacking of zinc-phthalocyanines (ZnPc), ZnPc-PI, for fluorescence imaging and mitochondria-targeted PDT. ZnPc-PI isolates and confines ZnPc PSs in the rigid nCOF to reduce AIQ, improve photostability, enhance cellular uptake, and increase the level of reactive oxygen species (ROS) generation via mitochondrial targeting. ZnPc-PI shows efficient tumor accumulation, which allowed precise tumor imaging and nanoparticle tracking. With high cellular uptake and tumor accumulation, intrinsic mitochondrial targeting, and enhanced ROS generation, ZnPc-PI exhibits potent PDT efficacy with >95% tumor growth inhibition on two murine colon cancer models without causing side effects.
- Subjects :
- Mice
Humans
Animals
Reactive Oxygen Species
Photosensitizing Agents pharmacology
Photosensitizing Agents therapeutic use
Isoindoles
Indoles pharmacology
Indoles therapeutic use
Mitochondria
Cell Line, Tumor
Photochemotherapy methods
Metal-Organic Frameworks therapeutic use
Neoplasms drug therapy
Organometallic Compounds pharmacology
Organometallic Compounds therapeutic use
Zinc Compounds
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 146
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 38134050
- Full Text :
- https://doi.org/10.1021/jacs.3c11092