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Catalytic, Antifungal, and Antiproliferative Activity Studies of a New Family of Mononuclear [V IV O]/[V V O 2 ] Complexes.
- Source :
-
Inorganic chemistry [Inorg Chem] 2024 Jan 08; Vol. 63 (1), pp. 714-729. Date of Electronic Publication: 2023 Dec 27. - Publication Year :
- 2024
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Abstract
- Ligands derived from 2-(1-phenylhydrazinyl)pyridine and salicylaldehyde (HL <superscript>1</superscript> ), 3-methoxysalicylaldehyde (HL <superscript>2</superscript> ), 5-bromosalicylaldehyde (HL <superscript>3</superscript> ), and 3,5-di- tert -butylsalicylaldehyde (HL <superscript>4</superscript> ) react with [V <superscript>IV</superscript> O(acac) <subscript>2</subscript> ] in MeOH followed by aerial oxidation to give [V <superscript>V</superscript> O <subscript>2</subscript> (L <superscript>1</superscript> )] ( 1 ), [V <superscript>V</superscript> O <subscript>2</subscript> (L <superscript>2</superscript> )] ( 2 ), [V <superscript>V</superscript> O <subscript>2</subscript> (L <superscript>3</superscript> )] ( 3 ), and [V <superscript>V</superscript> O <subscript>2</subscript> (L <superscript>4</superscript> )] ( 4 ). Complex [V <superscript>IV</superscript> O(acac)(L <superscript>1</superscript> )] ( 5 ) is also isolable from [V <superscript>IV</superscript> O(acac) <subscript>2</subscript> ] and HL <superscript>1</superscript> in dry MeOH. Structures of all complexes were confirmed by single-crystal X-ray and spectroscopic studies. They efficiently catalyze benzyl alcohol and its derivatives' oxidation in the presence of H <subscript>2</subscript> O <subscript>2</subscript> to their corresponding aldehydes. Under optimized reaction conditions using 1 as a catalyst precursor, conversion of benzyl alcohol follows the order: 4 (93%) > 2 (90%) > 1 (86%) > 3 (84%) ≈ 5 (84%). These complexes were also evaluated for antifungal and antiproliferative activities. Complex 3 with MIC <subscript>50</subscript> = 16 μg/mL, 4 with MIC <subscript>50</subscript> = 12 μg/mL, and 5 with MIC <subscript>50</subscript> = 16 μg/mL are efficient toward planktonic cells of Candida albicans and Candida tropicalis . On Michigan cancer foundation-7 (MCF-7) cells, they show comparable cytotoxic effects and exhibit IC <subscript>50</subscript> in the 27.3-33.5 μg/mL range, and among these, 4 exhibits the highest cytotoxicity. A similar study on human embryonic kidney cells (HEK293) confirms their less toxicity at lower concentrations (4 to 16 μg/mL) compared to MCF-7.
Details
- Language :
- English
- ISSN :
- 1520-510X
- Volume :
- 63
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Inorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38150362
- Full Text :
- https://doi.org/10.1021/acs.inorgchem.3c03665