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Ultrasound guided injection with Collagen-based Medical Device: real-life evaluation of efficacy and safety in hip osteoarthritis.
- Source :
-
Medical ultrasonography [Med Ultrason] 2024 Mar 27; Vol. 26 (1), pp. 26-31. Date of Electronic Publication: 2023 Nov 26. - Publication Year :
- 2024
-
Abstract
- Aims: Data regarding the treatment of hip osteoarthritis (OA) with collagen-based extracellular bio-scaffolds are lacking. We evaluated the treatment of hip OA with ultrasound guided intraarticular injections of Collagen-based Medical Device (CMD).<br />Material and Methods: Forty-four patients with Kellgren-Lawrence grade (KLG) I or II were selected, and 20/44 randomly selected patients (CMD group), were treated with 2 weekly consecutive ultrasound guided intraarticular injections of CMD (MD-HIP, Guna S.p.a. Milan, Italy). An additional 24/44 patients were treated with oral non-steroidal anti-inflammatory drugs (NSAIDs) daily (NSAIDs group). Clinical assessment, X-rays and ultrasound evaluation were performed at baseline, and after 1 month in both groups, and after 3 months in the CMD group. Outcome measures were general pain VAS (0-10), the whole WOMAC score, and the WOMAC specific subscores.<br />Results: CMD and NSAIDs group were homogenous for age, gender, VAS pain and WOMAC scores. The CMD group had significant improvement of the VAS pain (p<0.0001), global WOMAC score (p<0.0001) and WOMAC function (p<0.0001) from baseline to the 1st month, with further improvement from the 1st to the 3rd month (p<0,001; p<0.01; p<0.03, respectively). Significant improvement in WOMAC pain (p<0.0001) and WOMAC stiffness (p<0.0001) was detected at 1st month, with no significant change at 3rd month. In the NSAIDs group significant improvement in WOMAC function was detected after 1 month (p=0.021) only. No adverse events were recorded in the CMD and NSAIDs group.<br />Conclusion: The ultrasound guided intraarticular hip injections of CMD resulted in significant improvement in VAS pain and WOMAC scores compared to treatment with oral NSAIDs.
- Subjects :
- Humans
Treatment Outcome
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Pain
Injections, Intra-Articular
Collagen therapeutic use
Ultrasonography, Interventional
Osteoarthritis, Hip diagnostic imaging
Osteoarthritis, Hip drug therapy
Osteoarthritis, Hip chemically induced
Osteoarthritis, Knee
Subjects
Details
- Language :
- English
- ISSN :
- 2066-8643
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Medical ultrasonography
- Publication Type :
- Academic Journal
- Accession number :
- 38150696
- Full Text :
- https://doi.org/10.11152/mu-4242