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Unlocking the biosynthesis of psychedelic-inspired indolethylamines.
- Source :
-
Trends in biochemical sciences [Trends Biochem Sci] 2024 Mar; Vol. 49 (3), pp. 189-191. Date of Electronic Publication: 2023 Dec 29. - Publication Year :
- 2024
-
Abstract
- A recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.<br />Competing Interests: Declaration of interests J.A.J. is significant stakeholder at PsyBio Therapeutics, which has licensed tryptamine biosynthesis-related technology from Miami University. J.A.J. and A.K.S. are inventors on several related patent applications.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Subjects :
- N,N-Dimethyltryptamine
Hallucinogens pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0004
- Volume :
- 49
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Trends in biochemical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38160063
- Full Text :
- https://doi.org/10.1016/j.tibs.2023.12.009