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LncRNA CRNDE Drives the Progression of Hepatocellular Carcinoma by inducing the Immunosuppressive Niche.
- Source :
-
International journal of biological sciences [Int J Biol Sci] 2024 Jan 01; Vol. 20 (2), pp. 718-732. Date of Electronic Publication: 2024 Jan 01 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- As a crucial protumorigenic long noncoding RNA, colorectal tumor differential expression (CRNDE) has been confirmed to facilitate the progression of various cancers. However, its role in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) is still unclear. Here we determined that CRNDE was upregulated in HCC samples and that CRNDE-positive cells were predominantly enriched in malignant tumor cells. In vivo functional assays revealed that CRNDE-induced tumor cells supported HCC progression, recruited abundant granulocyte myeloid-derived suppressor cells (G-MDSCs) and restricted the infiltration of T cells. In terms of mechanisms, CRNDE bound with Toll-like receptor 3 (TLR3) and activated NF-κB signaling to increase the secretion of c-x-c motif chemokine ligand 3 (CXCL3). CRNDE knockdown could significantly suppress the accumulation of G-MDSCs and enhance the infiltration of T cells in the TME of HCC in vivo. Taken together, our study reveals the CRNDE-NF-κB-CXCL3 axis plays a crucial role in driving the immunosuppressive niche to facilitate HCC progression by recruiting G-MDSCs.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.<br /> (© The author(s).)
- Subjects :
- Humans
NF-kappa B metabolism
Cell Line, Tumor
Cell Proliferation genetics
Gene Expression Regulation, Neoplastic genetics
Tumor Microenvironment genetics
Carcinoma, Hepatocellular metabolism
RNA, Long Noncoding genetics
RNA, Long Noncoding metabolism
Liver Neoplasms genetics
Liver Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1449-2288
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of biological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38169579
- Full Text :
- https://doi.org/10.7150/ijbs.85471