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Low vitamin D levels are linked with increased cardiovascular disease risk in young adults: a sub-study and secondary analyses from the ACTIBATE randomized controlled trial.
- Source :
-
Journal of endocrinological investigation [J Endocrinol Invest] 2024 Jul; Vol. 47 (7), pp. 1645-1656. Date of Electronic Publication: 2024 Jan 04. - Publication Year :
- 2024
-
Abstract
- Purpose: Vitamin D deficiency is related to metabolic disturbances. Indeed, a poor vitamin D status has been usually detected in patients with cardiovascular disease (CVD). However, the relationship between vitamin D and CVD risk factors in young adults remains controversial at present. This study aimed to examine the association between circulating 25-hydroxivitamin D (25(OH)D) and CVD risk factors in young adults.<br />Methods: The present cross-sectional study included a cohort of 177 young adults aged 18-25 years old (65% women). 25(OH)D serum concentrations were assessed using a competitive chemiluminescence immunoassay. Fasting CVD risk factors (i.e., body composition, blood pressure, glucose metabolism, lipid profile, liver, and inflammatory markers) were determined by routine methods. A panel of 63 oxylipins and endocannabinoids (eCBs) was also analyzed by targeted metabolomics.<br />Results: Circulating 25(OH)D concentrations were inversely associated with a wide range of CVD risk factors including anthropometrical (all P ≤ 0.005), body composition (all P ≤ 0.038), glucose metabolism (all P ≤ 0.029), lipid profile (all P < 0.035), liver (all P ≤ 0.011), and pro-inflammatory biomarkers (all P ≤ 0.030). No associations of serum 25(OH)D concentrations were found with pro-inflammatory markers (all P ≥ 0.104), omega-6 and omega-3 oxylipins, nor eCBs concentrations or their analogs (all P ≥ 0.05).<br />Conclusion: The present findings support the idea that 25(OH)D could be a useful predictor of CVD risk in young individuals.<br /> (© 2024. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).)
- Subjects :
- Humans
Female
Male
Young Adult
Cross-Sectional Studies
Adult
Adolescent
Risk Factors
Biomarkers blood
Heart Disease Risk Factors
Cardiovascular Diseases blood
Cardiovascular Diseases etiology
Cardiovascular Diseases epidemiology
Vitamin D blood
Vitamin D analogs & derivatives
Vitamin D Deficiency blood
Vitamin D Deficiency epidemiology
Vitamin D Deficiency complications
Subjects
Details
- Language :
- English
- ISSN :
- 1720-8386
- Volume :
- 47
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of endocrinological investigation
- Publication Type :
- Academic Journal
- Accession number :
- 38172418
- Full Text :
- https://doi.org/10.1007/s40618-023-02272-4