Back to Search Start Over

A systematic analysis of anthocyanins inhibiting human, murine, and equine herpesviruses.

Authors :
Roll V
Diesendorf V
Roewer N
Abdelgawad A
Roewer J
Trimpert J
Bodem J
Source :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2024 Feb; Vol. 124, pp. 155314. Date of Electronic Publication: 2023 Dec 25.
Publication Year :
2024

Abstract

Background: Herpesviruses are common animal and human pathogens that cause severe health problems in children, immunocompromised patients, and infected animals with a host range from fish to mammals. Anthocyanin-containing plant extracts have been described as potent antivirals, which might cause fewer harmful side effects than direct-acting antivirals. Here, we report that an extract of Aristotelia chilensis (Molina) Stuntz (Elaeocarpaceae) (MBE) with a high content of the anthocyanin delphinidin suppresses lytic replication of equine, murine and human herpesviruses of replication in vitro.<br />Methods: We treated cultured cells with MBE and purified individual anthocyanins present in the extract to determine the most active compound at different concentrations. We subsequently infected the cultures with human herpesviruses 1 (HSV-1) or 8 (HHV-8), murine cytomegalovirus (CMV), or equine herpesviruses 1 (EHV-1) and determined the number of infected cells and viral infectivity.<br />Results: MBE inhibited the HSV-1, murine CMV, and EHV-1 by up to 2 orders of magnitude. In the presence of the stabilizing randomly methylated-beta-cyclodextrin, the inhibitory concentration could be lowered significantly. We identified delphinidin as an active antiviral compound and showed that the non-glycosylated delphinidin solved and stabilized with sulfobutylether-beta-cyclodextrin allowed usage of approximately 50 times lower concentrations.<br />Conclusion: Glycosylated delphinidin derivatives were identified as active antiviral compounds of MBE. This suggests that plant extracts rich in delphinidin-anthocyanins have potent antiviral properties that could be used in treatment and prevention.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier GmbH. All rights reserved.)

Details

Language :
English
ISSN :
1618-095X
Volume :
124
Database :
MEDLINE
Journal :
Phytomedicine : international journal of phytotherapy and phytopharmacology
Publication Type :
Academic Journal
Accession number :
38190783
Full Text :
https://doi.org/10.1016/j.phymed.2023.155314