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Trace metals and astrocytes physiology and pathophysiology.
- Source :
-
Cell calcium [Cell Calcium] 2024 Mar; Vol. 118, pp. 102843. Date of Electronic Publication: 2024 Jan 04. - Publication Year :
- 2024
-
Abstract
- Several trace metals, including iron, copper, manganese and zinc are essential for normal function of the nervous system. Both deficiency and excessive accumulation of these metals trigger neuropathological developments. The central nervous system (CNS) is in possession of dedicated homeostatic system that removes, accumulates, stores and releases these metals to fulfil nervous tissue demand. This system is mainly associated with astrocytes that act as dynamic reservoirs for trace metals, these being a part of a global system of CNS ionostasis. Here we overview physiological and pathophysiological aspects of astrocyte-cantered trace metals regulation.<br />Competing Interests: Declaration of competing interest Authors declare no conflict of interest.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Copper
Iron
Zinc
Astrocytes
Trace Elements
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1991
- Volume :
- 118
- Database :
- MEDLINE
- Journal :
- Cell calcium
- Publication Type :
- Academic Journal
- Accession number :
- 38199057
- Full Text :
- https://doi.org/10.1016/j.ceca.2024.102843