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A visible-light-induced bromine radical initiates direct C-H alkylation of heteroaromatics.

Authors :
Cao X
Wei L
Yang J
Song H
Wei Y
Source :
Organic & biomolecular chemistry [Org Biomol Chem] 2024 Feb 07; Vol. 22 (6), pp. 1157-1161. Date of Electronic Publication: 2024 Feb 07.
Publication Year :
2024

Abstract

Herein, a photoinduced direct C(sp <superscript>2</superscript> )-H alkylation of N -heteroaromatics by using commercially available tetrabutylammonium tribromide (TBATB) as a HAT reagent is described. The method uses O <subscript>2</subscript> as the oxidant, and features metal-free, mild reaction conditions and good functional group compatibility.

Details

Language :
English
ISSN :
1477-0539
Volume :
22
Issue :
6
Database :
MEDLINE
Journal :
Organic & biomolecular chemistry
Publication Type :
Academic Journal
Accession number :
38224149
Full Text :
https://doi.org/10.1039/d3ob02047a