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Elevated tissue expression of RANKL and RANK is associated with poorer survival rates in pancreatic cancer patients.
- Source :
-
Histology and histopathology [Histol Histopathol] 2024 Sep; Vol. 39 (9), pp. 1133-1140. Date of Electronic Publication: 2023 Dec 29. - Publication Year :
- 2024
-
Abstract
- Pancreatic cancer is a highly lethal malignancy with a growing incidence reported worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, which is often diagnosed at advanced stages, making its prognosis and medical management difficult. The identification of histopathological biomarkers has allowed a more precise stratification of pancreatic cancer patients, providing additional information about their prognosis and offering possible therapeutic targets to be explored. The prognostic value of the receptor activator of nuclear factor-kappa B (RANK) and its ligand (RANKL) has been evaluated in breast and prostate tumors, however, their usefulness has not been assessed in pancreatic cancer. In the present work, we analyzed the relationship between the protein expression of RANK and RANKL with the survival of 41 patients with pancreatic cancer followed for 60 months, by performing immunohistochemistry and Kaplan-Meier curves. Our results demonstrate a direct association of high expression levels of RANK and RANKL with poorer survival of pancreatic cancer patients in comparison to those with low/medium and null expression levels of both markers. Further studies should be conducted to explore the carcinogenic role of both components in this type of tumor, as well as additional promising translational uses.<br /> (©The Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License.)
- Subjects :
- Humans
Male
Female
Aged
Middle Aged
Prognosis
Survival Rate
Immunohistochemistry
Aged, 80 and over
Adult
Pancreatic Neoplasms mortality
Pancreatic Neoplasms metabolism
Pancreatic Neoplasms pathology
RANK Ligand metabolism
RANK Ligand biosynthesis
Receptor Activator of Nuclear Factor-kappa B metabolism
Biomarkers, Tumor metabolism
Biomarkers, Tumor analysis
Carcinoma, Pancreatic Ductal mortality
Carcinoma, Pancreatic Ductal metabolism
Carcinoma, Pancreatic Ductal pathology
Kaplan-Meier Estimate
Subjects
Details
- Language :
- English
- ISSN :
- 1699-5848
- Volume :
- 39
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Histology and histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 38230588
- Full Text :
- https://doi.org/10.14670/HH-18-700