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Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors.
- Source :
-
Cell reports. Medicine [Cell Rep Med] 2024 Feb 20; Vol. 5 (2), pp. 101380. Date of Electronic Publication: 2024 Jan 18. - Publication Year :
- 2024
-
Abstract
- Precise molecular characterization of circulating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is hampered by their mixed composition of mature and immature cells and lack of specific markers. Here, we focus on mature CD66b <superscript>+</superscript> CD10 <superscript>+</superscript> CD16 <superscript>+</superscript> CD11b <superscript>+</superscript> PMN-MDSCs (mPMN-MDSCs) from either cancer patients or healthy donors receiving G-CSF for stem cell mobilization (GDs). By RNA sequencing (RNA-seq) experiments, we report the identification of a distinct gene signature shared by the different mPMN-MDSC populations under investigation, also validated in mPMN-MDSCs from GDs and tumor-associated neutrophils (TANs) by single-cell RNA-seq (scRNA-seq) experiments. Analysis of such a gene signature uncovers a specific transcriptional program associated with mPMN-MDSC differentiation and allows us to identify that, in patients with either solid or hematologic tumors and in GDs, CD52, CD84, and prostaglandin E receptor 2 (PTGER2) represent potential mPMN-MDSC-associated markers. Altogether, our findings indicate that mature PMN-MDSCs distinctively undergo specific reprogramming during differentiation and lay the groundwork for selective immunomonitoring, and eventually targeting, of mature PMN-MDSCs.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Neutrophils
Receptors, Prostaglandin E, EP2 Subtype metabolism
Granulocyte Colony-Stimulating Factor pharmacology
Granulocyte Colony-Stimulating Factor metabolism
CD52 Antigen metabolism
Signaling Lymphocytic Activation Molecule Family metabolism
Myeloid-Derived Suppressor Cells metabolism
Myeloid-Derived Suppressor Cells pathology
Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2666-3791
- Volume :
- 5
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cell reports. Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38242120
- Full Text :
- https://doi.org/10.1016/j.xcrm.2023.101380