Back to Search
Start Over
Self-Propelled Nanomotor for Cancer Precision Combination Therapy.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2024 Jun; Vol. 13 (15), pp. e2304212. Date of Electronic Publication: 2024 Feb 07. - Publication Year :
- 2024
-
Abstract
- The emergence of nanomotor provides an innovative concept for tumor treatment strategies. Conventional chemotherapeutic agents for tumors exit various therapeutic constraints due to the unique microenvironment of the tumor itself. Calcium overload, the aberrant accumulation of free calcium ions in the cytoplasm, is a well-recognized contributor to damage and even cell death in numerous cell types. Such undesired destructive processes can be a novel means applicable to cancer ion interference therapy. Herein, the chemotherapeutic drug doxorubicin (DOX) and calcium peroxide as the driving force into nanomotors through a facile and understandable experimental scheme are successfully assembled. The modification of nucleic acid aptamer and NIR-II fluorescent molecules on its surface simultaneously strengthens both the active targeting and imaging capability of tumor loci. Therefore, by a comprehensive assessment of nanomotors both in vitro and in vivo experiments, CaO <subscript>2</subscript> /DOX@HPS-IR-1061-AS1411 demonstrates superior killing effects on tumor cells, and the intracellular reactive oxygen species produced by nanomotors is verified by molecular biology experiments to induce apoptosis of tumor cells and further achieve tumor therapeutic effects.<br /> (© 2024 Wiley‐VCH GmbH.)
- Subjects :
- Humans
Animals
Cell Line, Tumor
Mice
Reactive Oxygen Species metabolism
Peroxides chemistry
Peroxides pharmacology
Apoptosis drug effects
Aptamers, Nucleotide chemistry
Aptamers, Nucleotide pharmacology
Nanoparticles chemistry
Antineoplastic Agents pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Mice, Nude
Mice, Inbred BALB C
Doxorubicin pharmacology
Doxorubicin chemistry
Doxorubicin therapeutic use
Neoplasms drug therapy
Neoplasms metabolism
Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 13
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 38259234
- Full Text :
- https://doi.org/10.1002/adhm.202304212