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Bisphenol F affects neurodevelopmental gene expression, mushroom body development, and behavior in Drosophila melanogaster.
- Source :
-
Neurotoxicology and teratology [Neurotoxicol Teratol] 2024 Mar-Apr; Vol. 102, pp. 107331. Date of Electronic Publication: 2024 Jan 30. - Publication Year :
- 2024
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Abstract
- Bisphenol F (BPF) is a potential neurotoxicant used as a replacement for bisphenol A (BPA) in polycarbonate plastics and epoxy resins. We investigated the neurodevelopmental impacts of BPF exposure using Drosophila melanogaster as a model. Our transcriptomic analysis indicated that developmental exposure to BPF caused the downregulation of neurodevelopmentally relevant genes, including those associated with synapse formation and neuronal projection. To investigate the functional outcome of BPF exposure, we evaluated neurodevelopmental impacts across two genetic strains of Drosophila- w1118 (control) and the Fragile X Syndrome (FXS) model-by examining both behavioral and neuronal phenotypes. We found that BPF exposure in w1118 Drosophila caused hypoactive larval locomotor activity, decreased time spent grooming by adults, reduced courtship activity, and increased the severity but not frequency of β-lobe midline crossing defects by axons in the mushroom body. In contrast, although BPF reduced peristaltic contractions in FXS larvae, it had no impact on other larval locomotor phenotypes, grooming activity, or courtship activity. Strikingly, BPF exposure reduced both the severity and frequency of β-lobe midline crossing defects in the mushroom body of FXS flies, a phenotype previously observed in FXS flies exposed to BPA. This data indicates that BPF can affect neurodevelopment and its impacts vary depending on genetic background. Further, BPF may elicit a gene-environment interaction with Drosophila fragile X messenger ribonucleoprotein 1 (dFmr1)-the ortholog of human FMR1, which causes fragile X syndrome and is the most common monogenetic cause of intellectual disability and autism spectrum disorder.<br />Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kimberly Mulligan reports financial support was provided by National Institute of General Medical Sciences.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Humans
Drosophila melanogaster genetics
Drosophila melanogaster metabolism
Mushroom Bodies metabolism
Disease Models, Animal
Fragile X Mental Retardation Protein genetics
Fragile X Mental Retardation Protein metabolism
Drosophila
Benzhydryl Compounds toxicity
Gene Expression
Drosophila Proteins genetics
Drosophila Proteins metabolism
Fragile X Syndrome chemically induced
Fragile X Syndrome genetics
Fragile X Syndrome metabolism
Autism Spectrum Disorder metabolism
Phenols
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9738
- Volume :
- 102
- Database :
- MEDLINE
- Journal :
- Neurotoxicology and teratology
- Publication Type :
- Academic Journal
- Accession number :
- 38301979
- Full Text :
- https://doi.org/10.1016/j.ntt.2024.107331