Peri-lesion regions in differentiating suspicious breast calcification-only lesions specifically on contrast enhanced mammography.

Purpose: The explore the added value of peri-calcification regions on contrast-enhanced mammography (CEM) in the differential diagnosis of breast lesions presenting as only calcification on routine mammogram.
Methods: Patients who underwent CEM because of suspicious calcification-only lesions were included. The test set included patients between March 2017 and March 2019, while the validation set was collected between April 2019 and October 2019. The calcifications were automatically detected and grouped by a machine learning-based computer-aided system. In addition to extracting radiomic features on both low-energy (LE) and recombined (RC) images from the calcification areas, the peri-calcification regions, which is generated by extending the annotation margin radially with gradients from 1 mm to 9 mm, were attempted. Machine learning (ML) models were built to classify calcifications into malignant and benign groups. The diagnostic matrices were also evaluated by combing ML models with subjective reading.
Results: Models for LE (significant features: wavelet-LLL&#95;glcm&#95;Imc2&#95;MLO; wavelet-HLL&#95;firstorder&#95;Entropy&#95;MLO; wavelet-LHH&#95;glcm&#95;DifferenceVariance&#95;CC; wavelet-HLL&#95;glcm&#95;SumEntropy&#95;MLO;wavelet-HLH&#95;glrlm&#95;ShortRunLowGray LevelEmphasis&#95;MLO; original&#95;firstorder&#95;Entropy&#95;MLO; original&#95;shape&#95;Elongation&#95;MLO) and RC (significant features: wavelet-HLH&#95;glszm&#95;GrayLevelNonUniformityNormalized&#95;MLO; wavelet-LLH&#95;firstorder&#95;10Percentile&#95;CC; original&#95;firstorder&#95;Maximum&#95;MLO; wavelet-HHH&#95;glcm&#95;Autocorrelation&#95;MLO; original&#95;shape&#95;Elongation&#95;MLO; wavelet-LHL&#95;glszm&#95;GrayLevelNonUniformityNormalized&#95;MLO; wavelet-LLH&#95;firstorder&#95;RootMeanSquared&#95;MLO) images were set up with 7 features. Areas under the curve (AUCs) of RC models are significantly better than those of LE models with compact and expanded boundary (RC v.s. LE, compact: 0.81 v.s. 0.73, p < 0.05; expanded: 0.89 v.s. 0.81, p < 0.05) and RC models with 3 mm boundary extension yielded the best performance compared to those with other sizes (AUC = 0.89). Combining with radiologists' reading, the 3mm-boundary RC model achieved a sensitivity of 0.871 and negative predictive value of 0.937 with similar accuracy of 0.843 in predicting malignancy.
Conclusions: The machine learning model integrating intra- and peri-calcification regions on CEM has the potential to aid radiologists' performance in predicting malignancy of suspicious breast calcifications.