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Anticancer effect and laser photostability of ternary graphene oxide/chitosan/silver nanocomposites on various cancer cell lines.

Authors :
Ramadan MA
Sharaky M
Gad S
Ahmed HA
Jaremko M
Emwas AH
Faid AH
Source :
Nanomedicine (London, England) [Nanomedicine (Lond)] 2024 Apr; Vol. 19 (8), pp. 709-722. Date of Electronic Publication: 2024 Feb 07.
Publication Year :
2024

Abstract

Aims: The development of nanocomposites (NCs) of antitumor activity provides a new paradigm for fighting cancer. Here, a novel NC of green synthetic silver nanoparticles (AgNPs), graphene oxide (GO) and chitosan (Cs) NPs was developed. Materials & methods: The prepared GO/Cs/Ag NCs were analyzed using various techniques. Cytotoxicity of the NCs was evaluated against different cancer cell lines by Sulforhodamine B (SRB) assay. Results: GO/Cs/Ag NCs are novel and highly stable. UV-Vis showed two peaks at 227 and 469 nm, indicating the decoration of AgNPs on the surface of GO/Cs NPs. All tested cell lines were affected by GO/Cs NPs and GO/Cs/Ag NCs. Conclusion: The results indicate that GO/Cs/Ag NCs were present on tested cell lines and are a promising candidate for cancer therapy.

Details

Language :
English
ISSN :
1748-6963
Volume :
19
Issue :
8
Database :
MEDLINE
Journal :
Nanomedicine (London, England)
Publication Type :
Academic Journal
Accession number :
38323335
Full Text :
https://doi.org/10.2217/nnm-2023-0264