Role of IgG avidity in eyes with active Toxoplasma retinochoroiditis.

Authors :: Lakhmawar P
Kelgaonkar A
Patel A
Khalsa A
Basu S
Source :: Indian journal of ophthalmology [Indian J Ophthalmol] 2024 Jul 01; Vol. 72 (Suppl 4), pp. S601-S605. Date of Electronic Publication: 2024 Feb 05.
Publication Year :: 2024
Abstract: Purpose: To study the role of Toxoplasma IgG avidity in evaluating the stage of systemic infection during manifestation as toxoplasma retinochoroiditis and its clinical implications in eastern India.<br />Methods: Retrospective chart review of Toxoplasma retinochoroiditis cases with Toxoplasma serology for IgG, IgM, and IgG avidity.<br />Results: Included in this study were 17 eyes of 17 patients who had active retinitis located in the macula (14), mid-periphery (2), or periphery (1). They were either primary lesions (12) or reactivations (5). All the cases had Toxoplasma IgG positive; one case had IgM positivity, while all the cases had high IgG avidity values. IgG avidity had a positive correlation with the duration of symptoms.<br />Conclusion: We observed high IgG avidity values in active retinochoroiditis in both primary ocular Toxoplasmosis and reactivation subgroups. These results indicate a late ocular manifestation after initial systemic infection with a possible incubation period ranging from 5 weeks to 5 months.<br /> (Copyright © 2024 Copyright: © 2024 Indian Journal of Ophthalmology.)