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Effect of 2% meloxicam injection in Holstein dairy cows on acute clinical mastitis without systemic symptoms.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2024 Apr 01; Vol. 86 (4), pp. 374-380. Date of Electronic Publication: 2024 Feb 07. - Publication Year :
- 2024
-
Abstract
- This study aimed the efficacy of meloxicam (MX) in treating acute clinical mastitis (ACM) without systemic symptoms in Holstein cows by studying improvement in udder pain, changes in prostaglandin E <subscript>2</subscript> (PGE <subscript>2</subscript> ) and bradykinin (BK) levels in the milk, and milk yield (MY) after healing. Forty-two cows with ACM were randomly assigned to the MX treatment group (T group; n=21) and the control group (C group; n=21). At onset of illness (day 0), the T group received a 0.5 mg/kg subcutaneous (SC) injection of MX whereas the C group received 15 mL SC of saline solution as a placebo. Udder tenderness (UT) was measured, and milk samples were collected on days 0-3. There was little change in the MY of the T group before and after healing, whereas MY in the C group was significantly lower than after healing. UT on day 3 in the T group was significantly lower than that in the C group. PGE <subscript>2</subscript> levels significantly decreased from day 0 to day 3 in both groups. A significant negative correlation between PGE <subscript>2</subscript> and linear score was observed on day 1 in the T group, but not in the C group. In ACM without systemic symptoms, the administration MX may be useful for restoring MY and reducing udder pain after healing.
Details
- Language :
- English
- ISSN :
- 1347-7439
- Volume :
- 86
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 38325838
- Full Text :
- https://doi.org/10.1292/jvms.23-0424