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Clinical and molecular biomarkers predicting response to PARP inhibitors in ovarian cancer.
- Source :
-
Journal of gynecologic oncology [J Gynecol Oncol] 2024 Jul; Vol. 35 (4), pp. e55. Date of Electronic Publication: 2024 Jan 24. - Publication Year :
- 2024
-
Abstract
- Objective: To determine the useful biomarker for predicting the effects of poly-(ADP ribose)-polymerase (PARP) inhibitors in Japanese patients with ovarian cancer.<br />Methods: We collected clinical information and performed molecular biological analysis on 42 patients with ovarian, fallopian tube, and primary peritoneal carcinomas who received PARP inhibitors.<br />Results: Among the analyzed patients with ovarian cancer, 23.8% had germline BRCA mutation ( gBRCAm ), 42.9% had homologous recombination repair-related gene mutation (HRRm), and 61.1% had a genomic instability score (GIS) of ≥42. Patients with HRRm had a significantly longer progression-free survival (PFS) than those without HRRm (median PFS 35.6 vs. 7.9 months; p=0.009), with a particularly marked increase in PFS in patients with gBRCAm (median PFS 42.3 months). Similarly, among patients with recurrent ovarian cancer, those with HRRm had a longer PFS than those without HRRm (median PFS 42.3 vs. 7.7 months; p=0.040). Multivariate Cox proportional hazards regression analysis found that performance status and gBRCAm status were independent factors associated with prolonged PFS with PARP inhibitors. In recurrent ovarian cancer, multivariate regression analysis identified platinum-free interval (PFI) in addition to performance status as a significant predictor of PFS. On the contrary, no significant association was observed between PFS and a GIS of ≥42 used in clinical practice.<br />Conclusion: We found that HRRm can be a useful biomarker for predicting the effects of PARP inhibitors in treating ovarian cancer and that the PFI can also be useful in recurrent ovarian cancer.<br />Competing Interests: No potential conflict of interest relevant to this article was reported.<br /> (© 2024. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology.)
- Subjects :
- Humans
Female
Middle Aged
Aged
Adult
Germ-Line Mutation
Genomic Instability
Aged, 80 and over
Fallopian Tube Neoplasms drug therapy
Fallopian Tube Neoplasms genetics
Fallopian Tube Neoplasms mortality
Neoplasm Recurrence, Local genetics
Neoplasm Recurrence, Local drug therapy
Peritoneal Neoplasms drug therapy
Peritoneal Neoplasms genetics
Recombinational DNA Repair genetics
Recombinational DNA Repair drug effects
Poly(ADP-ribose) Polymerase Inhibitors therapeutic use
Ovarian Neoplasms drug therapy
Ovarian Neoplasms genetics
Ovarian Neoplasms mortality
Biomarkers, Tumor genetics
Progression-Free Survival
Subjects
Details
- Language :
- English
- ISSN :
- 2005-0399
- Volume :
- 35
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of gynecologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 38330378
- Full Text :
- https://doi.org/10.3802/jgo.2024.35.e55