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Highly Efficient Loading of Procaine on Water-Soluble Carbon Dots toward Long-Acting Anesthesia.
- Source :
-
The journal of physical chemistry. B [J Phys Chem B] 2024 Feb 22; Vol. 128 (7), pp. 1700-1710. Date of Electronic Publication: 2024 Feb 09. - Publication Year :
- 2024
-
Abstract
- Safe and efficient local anesthetic delivery carriers are crucial for long-term anesthesia and analgesics in clinical treatment. But currently, most of the local anesthetic carriers still have some disadvantages such as low drug-loading capacity, drug leakage, and potential side effects. Here, we report red-emissive carbon dots (Cys-CDs) synthesized by choosing cysteine and citric acid as precursors, which contain a large and intact sp <superscript>2</superscript> -domain with rich hydrophilic groups around the edge. The special structure of Cys-CDs is conducive to the efficient loading of procaine (PrC) via strong π-π stacking interactions. Based on the strong noncovalent interactions between them, the PrC loaded on Cys-CDs achieved slow release in vitro and had a long-lasting nerve blocking effect in vivo, which is 4-fold more than that of free PrC. More importantly, PrC/Cys-CDs do not cause any toxicity and inflammation during treatment owing to slow release of PrC and good water solubility of Cys-CDs, thus demonstrating the potential clinical application of CDs in long-lasting analgesia.
- Subjects :
- Anesthetics, Local
Procaine
Carbon chemistry
Water
Anesthesia
Quantum Dots chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5207
- Volume :
- 128
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The journal of physical chemistry. B
- Publication Type :
- Academic Journal
- Accession number :
- 38334803
- Full Text :
- https://doi.org/10.1021/acs.jpcb.3c07411