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OUTCOME OF EYES TREATED FOR RETINOPATHY OF PREMATURITY IN POSTERIOR ZONE I: An Eastern India Study.
- Source :
-
Retina (Philadelphia, Pa.) [Retina] 2024 Jun 01; Vol. 44 (6), pp. 1073-1082. - Publication Year :
- 2024
-
Abstract
- Purpose: To analyze the outcomes of eyes treated for retinopathy of prematurity in posterior Zone I.<br />Methods: In a part retrospective (9 years) and part prospective (1 year) interventional study, we analyzed eyes treated for retinopathy of prematurity in posterior Zone I with a minimum follow-up for 6 months.<br />Results: This study included 109 eyes of 56 infants; mean gestational age and birth weights were 29.3 (±2.1) weeks and 1112.5 (±381.9) g, respectively. The treatment included intravitreal anti-vascular endothelial growth factor as the initial treatment modality in 101 eyes (92.6%), either alone (27 eyes) or combined with laser or vitreous surgery (73 eyes). Laser was the initial treatment modality in eight eyes, either alone (n = 3) or in combination with surgery (n = 5). With anti-vascular endothelial growth factor alone, 30.68% (n = 27) eyes responded favorably, and the remaining 69.32% (n = 59) eyes needed retreatment (laser in the majority). At the final follow-up, 89.9% (out of 109) of eyes did well anatomically. Good outcome was significantly linked to no detachment at presentation ( P < 0.0001) and the presence of well-defined central vascular trunks ( P = 0.001).<br />Conclusion: Treating the eyes before retinal detachment with bevacizumab followed by laser (and surgery, if needed) results in a favorable outcome in babies with posterior Zone I retinopathy of prematurity.
- Subjects :
- Humans
Retrospective Studies
Female
Male
India epidemiology
Infant, Newborn
Prospective Studies
Follow-Up Studies
Vitrectomy methods
Treatment Outcome
Bevacizumab therapeutic use
Bevacizumab administration & dosage
Birth Weight
Infant
Visual Acuity
Retinopathy of Prematurity surgery
Retinopathy of Prematurity drug therapy
Retinopathy of Prematurity therapy
Retinopathy of Prematurity diagnosis
Angiogenesis Inhibitors therapeutic use
Angiogenesis Inhibitors administration & dosage
Intravitreal Injections
Gestational Age
Vascular Endothelial Growth Factor A antagonists & inhibitors
Laser Coagulation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1539-2864
- Volume :
- 44
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Retina (Philadelphia, Pa.)
- Publication Type :
- Academic Journal
- Accession number :
- 38346099
- Full Text :
- https://doi.org/10.1097/IAE.0000000000004067