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Sleep Duration Polygenic Risk and Phenotype: Associations with Biomarkers of Accelerated Aging in the Baltimore Longitudinal Study of Aging.
- Source :
-
International journal of aging & human development [Int J Aging Hum Dev] 2024 Feb 12, pp. 914150241231192. Date of Electronic Publication: 2024 Feb 12. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- We sought to explore whether genetic risk for, and self-reported, short sleep are associated with biological aging and whether age and sex moderate these associations. Participants were a subset of individuals from the Baltimore Longitudinal Study of Aging who had complete data on self-reported sleep ( n = 567) or genotype ( n = 367). Outcomes included: Intrinsic Horvath age, Hannum age, PhenoAge, GrimAge, and DNAm-based estimates of plasminogen activator inhibitor-1 (PAI-1) and granulocyte count. Results demonstrated that polygenic risk for short sleep was positively associated with granulocyte count; compared to those reporting <6 hr sleep, those reporting >7 hr demonstrated faster PhenoAge and GrimAge acceleration and higher estimated PAI-1. Polygenic risk for short sleep and self-reported sleep duration interacted with age and sex in their associations with some of the outcomes. Findings highlight that polygenic risk for short sleep and self-reported long sleep is associated with variation in the epigenetic landscape and subsequently aging.
Details
- Language :
- English
- ISSN :
- 1541-3535
- Database :
- MEDLINE
- Journal :
- International journal of aging & human development
- Publication Type :
- Academic Journal
- Accession number :
- 38347745
- Full Text :
- https://doi.org/10.1177/00914150241231192