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The characterization and analysis of the compound hemostatic cotton based on Ca 2+ /poly (vinyl alcohol)/soluble starch-fish skin collagen.

The characterization and analysis of the compound hemostatic cotton based on Ca 2+ /poly (vinyl alcohol)/soluble starch-fish skin collagen.

Authors :
Wang C
Guo J
Liu Q
Zeng X
Liu Y
Deng Y
Lin Y
Wu X
Deng H
Chen L
Weng W
Zhang Y
Source :
International journal of biological macromolecules [Int J Biol Macromol] 2024 Mar; Vol. 262 (Pt 2), pp. 130084. Date of Electronic Publication: 2024 Feb 11.
Publication Year :
2024

Abstract

Accidental bleeding is an unavoidable problem in daily life. To avoid the risk of excessive blood loss, it is urgent to design a functional material that can quickly stop bleeding. In this study, an efficient wound dressing for hemostasis was investigated. Based on the characteristics that Ca <superscript>2+</superscript> and fish skin collagen (FSC) could activate the coagulation mechanism, hemostatic cotton was prepared by solvent replacement method using CaCl <subscript>2</subscript> , FSC, soluble starch (SS), and polyvinyl alcohol (PVA) as raw materials. The cytotoxicity test showed the Ca <superscript>2+</superscript> PVA/FSC-SS hemostatic cottons had good biocompatibility. The activated partial thromboplastin time (APTT) of Ca <superscript>2+</superscript> PVA/FSC-SS(4) was 35.34 s, which was 22.07 s faster than that of PVA/FSC-SS, indicating Ca <superscript>2+</superscript> PVA/FSC-SS mediated the endogenous coagulation system. In vitro coagulation test, Ca <superscript>2+</superscript> PVA/FSC-SS(4) could stop bleeding rapidly within 39.60 ± 5.16 s, and the ability of wound healing was higher than commercial product (Celox). This study developed a rapid procoagulant and hemostatic material, which had a promising application in a variety of environments.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-0003
Volume :
262
Issue :
Pt 2
Database :
MEDLINE
Journal :
International journal of biological macromolecules
Publication Type :
Academic Journal
Accession number :
38350584
Full Text :
https://doi.org/10.1016/j.ijbiomac.2024.130084