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The characterization and analysis of the compound hemostatic cotton based on Ca 2+ /poly (vinyl alcohol)/soluble starch-fish skin collagen.
The characterization and analysis of the compound hemostatic cotton based on Ca 2+ /poly (vinyl alcohol)/soluble starch-fish skin collagen.
- Source :
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International journal of biological macromolecules [Int J Biol Macromol] 2024 Mar; Vol. 262 (Pt 2), pp. 130084. Date of Electronic Publication: 2024 Feb 11. - Publication Year :
- 2024
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Abstract
- Accidental bleeding is an unavoidable problem in daily life. To avoid the risk of excessive blood loss, it is urgent to design a functional material that can quickly stop bleeding. In this study, an efficient wound dressing for hemostasis was investigated. Based on the characteristics that Ca <superscript>2+</superscript> and fish skin collagen (FSC) could activate the coagulation mechanism, hemostatic cotton was prepared by solvent replacement method using CaCl <subscript>2</subscript> , FSC, soluble starch (SS), and polyvinyl alcohol (PVA) as raw materials. The cytotoxicity test showed the Ca <superscript>2+</superscript> PVA/FSC-SS hemostatic cottons had good biocompatibility. The activated partial thromboplastin time (APTT) of Ca <superscript>2+</superscript> PVA/FSC-SS(4) was 35.34 s, which was 22.07 s faster than that of PVA/FSC-SS, indicating Ca <superscript>2+</superscript> PVA/FSC-SS mediated the endogenous coagulation system. In vitro coagulation test, Ca <superscript>2+</superscript> PVA/FSC-SS(4) could stop bleeding rapidly within 39.60 ± 5.16 s, and the ability of wound healing was higher than commercial product (Celox). This study developed a rapid procoagulant and hemostatic material, which had a promising application in a variety of environments.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 262
- Issue :
- Pt 2
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 38350584
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2024.130084