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Fetal chronic hypoxia does not affect urinary presepsin levels in newborns at birth.
- Source :
-
Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2024 Feb 02; Vol. 62 (8), pp. 1643-1648. Date of Electronic Publication: 2024 Feb 02 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Objectives: Early sepsis detection and diagnosis still constitutes an open issue since the accuracy of standard-of care parameters is biased by a series of perinatal factors including hypoxia. Therefore, we aimed at investigating the effect of fetal chronic hypoxia insult on urine levels of a promising new marker of sepsis, namely presepsin (P-SEP).<br />Methods: We conducted a prospective case-control study in 22 cases of early-intrauterine growth restriction (E-IUGR) compared with 22 small-for-gestational-age (SGA) newborns and 66 healthy controls. P-SEP urine samples were collected over the first 72 h from birth. Blood culture and C-reactive protein (CRP) blood levels were measured in E-IUGR and SGA infants. Perinatal standard monitoring parameters and main outcomes were also recorded.<br />Results: No significant urinary P-SEP differences (p>0.05, for all) were observed among studied groups. Moreover, no significant correlations (p>0.05, for both) between urinary P-SEP and blood CRP levels in both E-IUGR and SGA groups (R=0.08; R=0.07, respectively) were observed.<br />Conclusions: The present results showing the lack of influence of fetal chronic hypoxia on urinary P-SEP levels offer additional data to hypothesize the possible use of urinary P-SEP measurement in neonates in daily clinical practice. Further multicenter prospective data are needed, including infants with early-onset sepsis.<br /> (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
- Subjects :
- Humans
Infant, Newborn
Female
Case-Control Studies
Prospective Studies
Male
Pregnancy
Fetal Hypoxia urine
Fetal Hypoxia diagnosis
Fetal Hypoxia blood
C-Reactive Protein analysis
Biomarkers urine
Biomarkers blood
Infant, Small for Gestational Age
Fetal Growth Retardation urine
Fetal Growth Retardation diagnosis
Fetal Growth Retardation blood
Sepsis urine
Sepsis diagnosis
Sepsis blood
Peptide Fragments urine
Peptide Fragments blood
Lipopolysaccharide Receptors
Subjects
Details
- Language :
- English
- ISSN :
- 1437-4331
- Volume :
- 62
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Clinical chemistry and laboratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38353160
- Full Text :
- https://doi.org/10.1515/cclm-2023-1308