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Fetal chronic hypoxia does not affect urinary presepsin levels in newborns at birth.

Authors :
D'Adamo E
Levantini G
Librandi M
Botondi V
Di Ricco L
De Sanctis S
Spagnuolo C
Gazzolo F
Gavilanes DA
Di Gregorio P
Di Monte J
Strozzi MC
Maconi A
Cassinari M
Libener R
Gazzolo D
Source :
Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2024 Feb 02; Vol. 62 (8), pp. 1643-1648. Date of Electronic Publication: 2024 Feb 02 (Print Publication: 2024).
Publication Year :
2024

Abstract

Objectives: Early sepsis detection and diagnosis still constitutes an open issue since the accuracy of standard-of care parameters is biased by a series of perinatal factors including hypoxia. Therefore, we aimed at investigating the effect of fetal chronic hypoxia insult on urine levels of a promising new marker of sepsis, namely presepsin (P-SEP).<br />Methods: We conducted a prospective case-control study in 22 cases of early-intrauterine growth restriction (E-IUGR) compared with 22 small-for-gestational-age (SGA) newborns and 66 healthy controls. P-SEP urine samples were collected over the first 72 h from birth. Blood culture and C-reactive protein (CRP) blood levels were measured in E-IUGR and SGA infants. Perinatal standard monitoring parameters and main outcomes were also recorded.<br />Results: No significant urinary P-SEP differences (p>0.05, for all) were observed among studied groups. Moreover, no significant correlations (p>0.05, for both) between urinary P-SEP and blood CRP levels in both E-IUGR and SGA groups (R=0.08; R=0.07, respectively) were observed.<br />Conclusions: The present results showing the lack of influence of fetal chronic hypoxia on urinary P-SEP levels offer additional data to hypothesize the possible use of urinary P-SEP measurement in neonates in daily clinical practice. Further multicenter prospective data are needed, including infants with early-onset sepsis.<br /> (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)

Details

Language :
English
ISSN :
1437-4331
Volume :
62
Issue :
8
Database :
MEDLINE
Journal :
Clinical chemistry and laboratory medicine
Publication Type :
Academic Journal
Accession number :
38353160
Full Text :
https://doi.org/10.1515/cclm-2023-1308