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Egg White Hydrolysate Mitigates Cadmium-induced Neurological Disorders and Oxidative Damage.

Authors :
Pinheiro Júnior JEG
Sosa PM
das Neves BS
Vassallo DV
Peçanha FM
Miguel-Castro M
Mello-Carpes PB
Wiggers GA
Source :
Neurochemical research [Neurochem Res] 2024 Jun; Vol. 49 (6), pp. 1603-1615. Date of Electronic Publication: 2024 Feb 14.
Publication Year :
2024

Abstract

We aimed to investigate whether the consumption of Egg White Hydrolysate (EWH) acts on nervous system disorders induced by exposure to Cadmium (Cd) in rats. Male Wistar rats were divided into (a) Control (Ct): H <subscript>2</subscript> O by gavage for 28 days + H <subscript>2</subscript> O (i.p. - 15th - 28th day); (b) Cadmium (Cd): H <subscript>2</subscript> O by gavage + CdCl <subscript>2</subscript> - 1 mg/kg/day (i.p. - 15th - 28th day); (c) EWH 14d: EWH 1 g/kg/day by gavage for 14 days + H <subscript>2</subscript> O (i.p.- 15th - 28th day); (d) Cd + EWH cotreatment (Cd + EWHco): CdCl <subscript>2</subscript>  + EWH for 14 days; (e) EWH 28d: EWH for 28 days; (f) EWHpre + Cd: EWH (1st - 28th day) + CdCl <subscript>2</subscript> (15th - 28th day). At the beginning and the end of treatment, neuromotor performance (Neurological Deficit Scale); motor function (Rota-Rod test); ability to move and explore (Open Field test); thermal sensitivity (Hot Plate test); and state of anxiety (Elevated Maze test) were tested. The antioxidant status in the cerebral cortex and the striatum were biochemically analyzed. Cd induces anxiety, and neuromotor, and thermal sensitivity deficits. EWH consumption prevented anxiety, neuromotor deficits, and alterations in thermal sensitivity, avoiding neuromotor deficits both when the administration was performed before or during Cd exposure. Both modes of administration reduced the levels of reactive species, and the lipid peroxidation increased by Cd and improved the striatum's antioxidant capacity. Pretreatment proved to be beneficial in preventing the reduction of SOD activity in the cortex. EWH could be used as a functional food with antioxidant properties capable of preventing neurological damage induced by Cd.<br /> (© 2024. The Author(s).)

Details

Language :
English
ISSN :
1573-6903
Volume :
49
Issue :
6
Database :
MEDLINE
Journal :
Neurochemical research
Publication Type :
Academic Journal
Accession number :
38353895
Full Text :
https://doi.org/10.1007/s11064-024-04110-2