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Egg White Hydrolysate Mitigates Cadmium-induced Neurological Disorders and Oxidative Damage.
- Source :
-
Neurochemical research [Neurochem Res] 2024 Jun; Vol. 49 (6), pp. 1603-1615. Date of Electronic Publication: 2024 Feb 14. - Publication Year :
- 2024
-
Abstract
- We aimed to investigate whether the consumption of Egg White Hydrolysate (EWH) acts on nervous system disorders induced by exposure to Cadmium (Cd) in rats. Male Wistar rats were divided into (a) Control (Ct): H <subscript>2</subscript> O by gavage for 28 days + H <subscript>2</subscript> O (i.p. - 15th - 28th day); (b) Cadmium (Cd): H <subscript>2</subscript> O by gavage + CdCl <subscript>2</subscript> - 1 mg/kg/day (i.p. - 15th - 28th day); (c) EWH 14d: EWH 1 g/kg/day by gavage for 14 days + H <subscript>2</subscript> O (i.p.- 15th - 28th day); (d) Cd + EWH cotreatment (Cd + EWHco): CdCl <subscript>2</subscript> + EWH for 14 days; (e) EWH 28d: EWH for 28 days; (f) EWHpre + Cd: EWH (1st - 28th day) + CdCl <subscript>2</subscript> (15th - 28th day). At the beginning and the end of treatment, neuromotor performance (Neurological Deficit Scale); motor function (Rota-Rod test); ability to move and explore (Open Field test); thermal sensitivity (Hot Plate test); and state of anxiety (Elevated Maze test) were tested. The antioxidant status in the cerebral cortex and the striatum were biochemically analyzed. Cd induces anxiety, and neuromotor, and thermal sensitivity deficits. EWH consumption prevented anxiety, neuromotor deficits, and alterations in thermal sensitivity, avoiding neuromotor deficits both when the administration was performed before or during Cd exposure. Both modes of administration reduced the levels of reactive species, and the lipid peroxidation increased by Cd and improved the striatum's antioxidant capacity. Pretreatment proved to be beneficial in preventing the reduction of SOD activity in the cortex. EWH could be used as a functional food with antioxidant properties capable of preventing neurological damage induced by Cd.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Male
Rats
Antioxidants pharmacology
Antioxidants therapeutic use
Nervous System Diseases chemically induced
Nervous System Diseases prevention & control
Nervous System Diseases drug therapy
Protein Hydrolysates pharmacology
Protein Hydrolysates therapeutic use
Neuroprotective Agents therapeutic use
Neuroprotective Agents pharmacology
Rats, Wistar
Oxidative Stress drug effects
Cadmium toxicity
Egg White chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1573-6903
- Volume :
- 49
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neurochemical research
- Publication Type :
- Academic Journal
- Accession number :
- 38353895
- Full Text :
- https://doi.org/10.1007/s11064-024-04110-2