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The multifaceted role of the CXC chemokines and receptors signaling axes in ALS pathophysiology.
- Source :
-
Progress in neurobiology [Prog Neurobiol] 2024 Apr; Vol. 235, pp. 102587. Date of Electronic Publication: 2024 Feb 15. - Publication Year :
- 2024
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Abstract
- Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disease with complex genetic basis and still no clear etiology. Multiple intertwined layers of immune system-related dysfunctions and neuroinflammatory mechanisms are emerging as substantial determinants in ALS onset and progression. In this review, we collect the increasingly arising evidence implicating four main CXC chemokines/cognate receptors signaling axes (CXCR1/2-CXCL1/2/8; CXCR3-CXCL9/10/11; CXCR4/7-CXCL12; CXCR5-CXCL13) in the pathophysiology of ALS. Findings in preclinical models implicate these signaling pathways in motor neuron toxicity and neuroprotection, while in ALS patients dysregulation of CXCLs/CXCRs has been shown at both central and peripheral levels. Immunological monitoring of CXC-ligands in ALS may allow tracking of disease progression, while pharmacological modulation of CXC-receptors provides a novel therapeutic strategy. A deeper understanding of the interplay between CXC-mediated neuroinflammation and ALS is crucial to advance research into treatments for this debilitating uncurable disorder.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Humans
Signal Transduction
Motor Neurons
Amyotrophic Lateral Sclerosis
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5118
- Volume :
- 235
- Database :
- MEDLINE
- Journal :
- Progress in neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 38367748
- Full Text :
- https://doi.org/10.1016/j.pneurobio.2024.102587